FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220796558> ?p ?o ?g. }

• W4220796558 endingPage "100237" @default.
• W4220796558 startingPage "100237" @default.
• W4220796558 abstract "Three-dimensional printing (3D printing) is a promising technique for producing scaffolds for bone tissue engineering applications. Porous scaffolds can be printed directly, and the design, shape and porosity can be controlled. 3D synthetic biodegradable polymeric scaffolds intended for in situ bone regeneration must meet stringent criteria, primarily appropriate mechanical properties, good 3D design, adequate biocompatibility and the ability to enhance bone formation. In this study, healing of critical-sized (5 ​mm) femur defects of rats was enhanced by implanting two different designs of 3D printed poly(l-lactide-co-ε-caprolactone) (poly(LA-co-CL)) scaffolds seeded with rat bone marrow mesenchymal stem cells (rBMSC), which had been pre-differentiated in vitro into cartilage-forming chondrocytes. Depending on the design, the scaffolds had an interconnected porous structure of 300-500 ​μm and porosity of 50-65%. According to a computational simulation, the internal force distribution was consistent with scaffold designs and comparable between the two designs. Moreover, the defects treated with 3D-printed scaffolds seeded with chondrocyte-like cells exhibited significantly increased bone formation up to 15 weeks compared with empty defects. In all experimental animals, bone metabolic activity was monitored by positron emission tomography 1, 3, 5, 7, 11 and 14 weeks after surgery. This demonstrated a time-dependent relationship between scaffold design and metabolic activity. This confirmed that successful regeneration was highly reproducible. The in vitro and in vivo data indicated that the experimental setups had promising outcomes and could facilitate new bone formation through endochondral ossification." @default.
• W4220796558 created "2022-04-03" @default.
• W4220796558 creator A5001078410 @default.
• W4220796558 creator A5006163897 @default.
• W4220796558 creator A5008328392 @default.
• W4220796558 creator A5017412808 @default.
• W4220796558 creator A5029330148 @default.
• W4220796558 creator A5031475469 @default.
• W4220796558 creator A5044067814 @default.
• W4220796558 creator A5067636316 @default.
• W4220796558 creator A5071772189 @default.
• W4220796558 date "2022-03-01" @default.
• W4220796558 modified "2023-10-18" @default.
• W4220796558 title "Efficacy of treating segmental bone defects through endochondral ossification: 3D printed designs and bone metabolic activities" @default.
• W4220796558 cites W1494689048 @default.
• W4220796558 cites W1566227297 @default.
• W4220796558 cites W1581527645 @default.
• W4220796558 cites W1766872465 @default.
• W4220796558 cites W1937982182 @default.
• W4220796558 cites W1964794578 @default.
• W4220796558 cites W1966418055 @default.
• W4220796558 cites W1968042933 @default.
• W4220796558 cites W1968069093 @default.
• W4220796558 cites W1973497510 @default.
• W4220796558 cites W1979169277 @default.
• W4220796558 cites W1984589322 @default.
• W4220796558 cites W1985206216 @default.
• W4220796558 cites W1996361385 @default.
• W4220796558 cites W2001241369 @default.
• W4220796558 cites W2002963723 @default.
• W4220796558 cites W2007310752 @default.
• W4220796558 cites W2013148027 @default.
• W4220796558 cites W2015518562 @default.
• W4220796558 cites W2021773986 @default.
• W4220796558 cites W2022745055 @default.
• W4220796558 cites W2030455448 @default.
• W4220796558 cites W2032740145 @default.
• W4220796558 cites W2034310880 @default.
• W4220796558 cites W2042932723 @default.
• W4220796558 cites W2048644480 @default.
• W4220796558 cites W2051400613 @default.
• W4220796558 cites W2054859965 @default.
• W4220796558 cites W2064430858 @default.
• W4220796558 cites W2066549760 @default.
• W4220796558 cites W2067716147 @default.
• W4220796558 cites W2114539651 @default.
• W4220796558 cites W2121822288 @default.
• W4220796558 cites W2131229281 @default.
• W4220796558 cites W2134599508 @default.
• W4220796558 cites W2134820353 @default.
• W4220796558 cites W2137087836 @default.
• W4220796558 cites W2141577002 @default.
• W4220796558 cites W2146204519 @default.
• W4220796558 cites W2157664121 @default.
• W4220796558 cites W2161561471 @default.
• W4220796558 cites W2199647736 @default.
• W4220796558 cites W2273582075 @default.
• W4220796558 cites W2288587909 @default.
• W4220796558 cites W2307984414 @default.
• W4220796558 cites W2340247101 @default.
• W4220796558 cites W2432015496 @default.
• W4220796558 cites W2531779058 @default.
• W4220796558 cites W2533394841 @default.
• W4220796558 cites W2561565313 @default.
• W4220796558 cites W2581486461 @default.
• W4220796558 cites W2598108676 @default.
• W4220796558 cites W2611143088 @default.
• W4220796558 cites W2619952187 @default.
• W4220796558 cites W2746536920 @default.
• W4220796558 cites W2766666314 @default.
• W4220796558 cites W2767897373 @default.
• W4220796558 cites W2779703805 @default.
• W4220796558 cites W2792859335 @default.
• W4220796558 cites W2800159482 @default.
• W4220796558 cites W2801449280 @default.
• W4220796558 cites W2888878293 @default.
• W4220796558 cites W291706188 @default.
• W4220796558 cites W2923711003 @default.
• W4220796558 cites W2947054202 @default.
• W4220796558 cites W2951014231 @default.
• W4220796558 cites W2954612556 @default.
• W4220796558 cites W2963953143 @default.
• W4220796558 cites W2978703216 @default.
• W4220796558 cites W2989009760 @default.
• W4220796558 cites W3020471480 @default.
• W4220796558 cites W3092659393 @default.
• W4220796558 cites W3167546054 @default.
• W4220796558 cites W3173441734 @default.
• W4220796558 cites W3207458634 @default.
• W4220796558 doi "https://doi.org/10.1016/j.mtbio.2022.100237" @default.
• W4220796558 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35280332" @default.
• W4220796558 hasPublicationYear "2022" @default.
• W4220796558 type Work @default.
• W4220796558 citedByCount "6" @default.
• W4220796558 countsByYear W42207965582022 @default.
• W4220796558 countsByYear W42207965582023 @default.
• W4220796558 crossrefType "journal-article" @default.
• W4220796558 hasAuthorship W4220796558A5001078410 @default.

• next