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- W4220796673 abstract "Abstract Multinucleated osteoclasts, essential for skeletal remodeling in health and diseases, are formed by fusion of osteoclast precursors with each fusion event raising their bone-resorbing activity. Here we report that nuclear RNA chaperone, La protein moonlights as an osteoclast fusion regulator. Monocyte-to-osteoclast differentiation starts with a drastic decrease in La levels. Then La reappears as a proteasecleaved species at the cell surface where it promotes fusion by mechanisms independent of La-RNA interactions. Appearance-and-disappearance of cell-surface La act as an on-and-off switch of the fusion activity with fusion slowing down when surface La is replaced in mature osteoclasts by full-length nuclear La. Inhibiting surface La in a novel explant model of fibrous dysplasia inhibits excessive osteoclast formation characteristic of this disease, highlighting La’s potential as a therapeutic target. One-Sentence Summary A nuclear RNA chaperon moves to the surface of osteoclasts to control their formation and function in bone metabolism." @default.
- W4220796673 created "2022-04-03" @default.
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- W4220796673 date "2022-03-08" @default.
- W4220796673 modified "2023-09-28" @default.
- W4220796673 title "Cell Surface-Bound La Protein Regulates The Cell Fusion Stage Of Osteoclastogenesis" @default.
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- W4220796673 doi "https://doi.org/10.1101/2022.03.08.479741" @default.
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