Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220796923> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W4220796923 abstract "Abstract Glioblastoma (GBM) is the worst and most common malignant intracranial tumor with high mortality rates and almost invariably poor prognosis even after surgery, radiotherapy, chemotherapy and emerging immunotherapies. Therefore, it is important to find new therapeutic drugs for GBM treatment. In the present study, we aimed to explore the effect of one natural chalcone—Isobavachalcone (IBC) on GBM and clarify its anti-cancer mechanisms. It was observed that IBC could inhibit GBM cell proliferation, migration and invasion in vitro and prevent tumor growth without any significant drug toxicity in vivo . Mechanistically, IBC may target NOD-like receptor family pyrin domain-containing 3 (NLRP3) transcription factor estrogen receptor 1 (ESR1) by network pharmacology and molecular docking analysis. Experimentally, IBC reduced NLRP3 inflammasome-related pyroptosis and inflammation, arrested cell cycle at G1 phase, and induced mitochondria-dependent apoptosis in GBM cells. These results indicated that IBC is a potential therapeutic drug against GBM and provide a new insight into GBM treatment." @default.
- W4220796923 created "2022-04-03" @default.
- W4220796923 creator A5023539921 @default.
- W4220796923 creator A5028009429 @default.
- W4220796923 creator A5034043655 @default.
- W4220796923 creator A5038531504 @default.
- W4220796923 creator A5056225579 @default.
- W4220796923 creator A5075056322 @default.
- W4220796923 creator A5078572397 @default.
- W4220796923 creator A5080084558 @default.
- W4220796923 date "2022-03-16" @default.
- W4220796923 modified "2023-10-16" @default.
- W4220796923 title "Isobavachalcone Attenuates NLRP3 Inflammasome-related Pyroptosis and Induces Apoptosis via Arresting Cell Cycle in Glioblastoma" @default.
- W4220796923 doi "https://doi.org/10.21203/rs.3.rs-1416834/v1" @default.
- W4220796923 hasPublicationYear "2022" @default.
- W4220796923 type Work @default.
- W4220796923 citedByCount "1" @default.
- W4220796923 countsByYear W42207969232022 @default.
- W4220796923 crossrefType "posted-content" @default.
- W4220796923 hasAuthorship W4220796923A5023539921 @default.
- W4220796923 hasAuthorship W4220796923A5028009429 @default.
- W4220796923 hasAuthorship W4220796923A5034043655 @default.
- W4220796923 hasAuthorship W4220796923A5038531504 @default.
- W4220796923 hasAuthorship W4220796923A5056225579 @default.
- W4220796923 hasAuthorship W4220796923A5075056322 @default.
- W4220796923 hasAuthorship W4220796923A5078572397 @default.
- W4220796923 hasAuthorship W4220796923A5080084558 @default.
- W4220796923 hasBestOaLocation W42207969231 @default.
- W4220796923 hasConcept C105696609 @default.
- W4220796923 hasConcept C139174496 @default.
- W4220796923 hasConcept C150903083 @default.
- W4220796923 hasConcept C17172800 @default.
- W4220796923 hasConcept C190283241 @default.
- W4220796923 hasConcept C203014093 @default.
- W4220796923 hasConcept C207001950 @default.
- W4220796923 hasConcept C2776914184 @default.
- W4220796923 hasConcept C2777209026 @default.
- W4220796923 hasConcept C2777389519 @default.
- W4220796923 hasConcept C2778227246 @default.
- W4220796923 hasConcept C29537977 @default.
- W4220796923 hasConcept C502942594 @default.
- W4220796923 hasConcept C55493867 @default.
- W4220796923 hasConcept C71924100 @default.
- W4220796923 hasConcept C86803240 @default.
- W4220796923 hasConcept C98274493 @default.
- W4220796923 hasConceptScore W4220796923C105696609 @default.
- W4220796923 hasConceptScore W4220796923C139174496 @default.
- W4220796923 hasConceptScore W4220796923C150903083 @default.
- W4220796923 hasConceptScore W4220796923C17172800 @default.
- W4220796923 hasConceptScore W4220796923C190283241 @default.
- W4220796923 hasConceptScore W4220796923C203014093 @default.
- W4220796923 hasConceptScore W4220796923C207001950 @default.
- W4220796923 hasConceptScore W4220796923C2776914184 @default.
- W4220796923 hasConceptScore W4220796923C2777209026 @default.
- W4220796923 hasConceptScore W4220796923C2777389519 @default.
- W4220796923 hasConceptScore W4220796923C2778227246 @default.
- W4220796923 hasConceptScore W4220796923C29537977 @default.
- W4220796923 hasConceptScore W4220796923C502942594 @default.
- W4220796923 hasConceptScore W4220796923C55493867 @default.
- W4220796923 hasConceptScore W4220796923C71924100 @default.
- W4220796923 hasConceptScore W4220796923C86803240 @default.
- W4220796923 hasConceptScore W4220796923C98274493 @default.
- W4220796923 hasLocation W42207969231 @default.
- W4220796923 hasOpenAccess W4220796923 @default.
- W4220796923 hasPrimaryLocation W42207969231 @default.
- W4220796923 hasRelatedWork W1970045743 @default.
- W4220796923 hasRelatedWork W2123730023 @default.
- W4220796923 hasRelatedWork W2154629127 @default.
- W4220796923 hasRelatedWork W2891937576 @default.
- W4220796923 hasRelatedWork W2912550910 @default.
- W4220796923 hasRelatedWork W2969256284 @default.
- W4220796923 hasRelatedWork W3031498149 @default.
- W4220796923 hasRelatedWork W3200135840 @default.
- W4220796923 hasRelatedWork W4225424769 @default.
- W4220796923 hasRelatedWork W4226305429 @default.
- W4220796923 isParatext "false" @default.
- W4220796923 isRetracted "false" @default.
- W4220796923 workType "article" @default.