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- W4220797012 abstract "Purpose: The aim of this study is to evaluate, safety, tolerability, pharmacokinetic and pharmacodynamic profiles of iN1011-N17 in healthy volunteers as well as its formulation effect. Voltage-gated sodium channels (VGSCs) showed a significant role in regulating neuronal excitability in normal and pathological pain states. It is now known that the VGSC family consists of nine members, Nav1.1-1.9 encoded by the SCN1A-SCN5A and SCN8A-SCN11A genes. The expression of these sodium channel isoforms is spatially and temporally regulated, and they possess distinct electrophysiological properties." @default.
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- W4220797012 date "2022-04-01" @default.
- W4220797012 modified "2023-09-28" @default.
- W4220797012 title "SAFETY, TOLERABILITY AND PHARMACOKINETICS/PHARMACODYNAMIC EVALUATION OF PROPERTIES OF IN1011-N17 AFTER ORAL ADMINISTRATION IN HEALTHY VOLUNTEERS WITH EFFECT COMPARISON OF SOLUBILITY ENHANCED FORMULATION." @default.
- W4220797012 doi "https://doi.org/10.1016/j.joca.2022.02.076" @default.
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