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- W4220797130 abstract "Patients diagnosed with basal-like breast cancer face a more aggressive disease course and more dismal prognosis than patients diagnosed with luminal A and luminal B breast cancer molecular subtypes (1-4). We mined published microarray data (5, 6) to understand in an unbiased fashion the most distinguishing transcriptional features of tumors from patients with basal or basal-like subtype breast cancer. We observed transcriptome-wide differential expression of intercellular adhesion molecule 1, ICAM1, when comparing tumors of patients with basal-like breast cancer with that of other PAM50 molecular subtypes. ICAM1 mRNA was present at significantly higher quantities in the tumors of patients with basal-like breast cancer. Analysis of patient survival data revealed that ICAM1 primary tumor expression was correlated with distant metastasis-free survival in basal subtype breast cancer. Elevated ICAM1 expression appears to distinguish basal-like human breast cancer from the other molecular subtypes." @default.
- W4220797130 created "2022-04-03" @default.
- W4220797130 creator A5024900493 @default.
- W4220797130 date "2022-03-25" @default.
- W4220797130 modified "2023-09-25" @default.
- W4220797130 title "Elevated ICAM1 expression distinguishes basal-like human breast cancer." @default.
- W4220797130 doi "https://doi.org/10.31219/osf.io/gkbpy" @default.
- W4220797130 hasPublicationYear "2022" @default.
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