Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220797271> ?p ?o ?g. }
- W4220797271 abstract "Abstract DNA damage and repair studies are at the core of the radiation biology field and represent also the fundamental principles informing radiation therapy (RT). DNA damage levels are a function of radiation dose, whereas the type of damage and biological effects such as DNA damage complexity, depend on radiation quality that is linear energy transfer (LET). Both levels and types of DNA damage determine cell fate, which can include necrosis, apoptosis, senescence or autophagy. Herein, we present an overview of current RT modalities in the light of DNA damage and repair with emphasis on medium to high-LET radiation. Proton radiation is discussed along with its new adaptation of FLASH RT. RT based on α -particles includes brachytherapy and nuclear-RT, that is proton-boron capture therapy (PBCT) and boron-neutron capture therapy (BNCT). We also discuss carbon ion therapy along with combinatorial immune-based therapies and high-LET RT. For each RT modality, we summarise relevant DNA damage studies. Finally, we provide an update of the role of DNA repair in high-LET RT and we explore the biological responses triggered by differential LET and dose." @default.
- W4220797271 created "2022-04-03" @default.
- W4220797271 creator A5016235730 @default.
- W4220797271 creator A5035239095 @default.
- W4220797271 creator A5053902049 @default.
- W4220797271 creator A5056549906 @default.
- W4220797271 creator A5057104449 @default.
- W4220797271 creator A5060059045 @default.
- W4220797271 creator A5070934027 @default.
- W4220797271 creator A5075254077 @default.
- W4220797271 creator A5082801249 @default.
- W4220797271 date "2022-01-01" @default.
- W4220797271 modified "2023-10-16" @default.
- W4220797271 title "Key biological mechanisms involved in high-LET radiation therapies with a focus on DNA damage and repair" @default.
- W4220797271 cites W1533229981 @default.
- W4220797271 cites W179102062 @default.
- W4220797271 cites W1960277249 @default.
- W4220797271 cites W1964642360 @default.
- W4220797271 cites W1964697571 @default.
- W4220797271 cites W1967251446 @default.
- W4220797271 cites W1970924670 @default.
- W4220797271 cites W1973405668 @default.
- W4220797271 cites W1975125562 @default.
- W4220797271 cites W1981205626 @default.
- W4220797271 cites W1982531806 @default.
- W4220797271 cites W1983466632 @default.
- W4220797271 cites W1983948531 @default.
- W4220797271 cites W1987364842 @default.
- W4220797271 cites W1992430346 @default.
- W4220797271 cites W1996315957 @default.
- W4220797271 cites W1998024857 @default.
- W4220797271 cites W2000590852 @default.
- W4220797271 cites W2002879660 @default.
- W4220797271 cites W2004032403 @default.
- W4220797271 cites W2004823560 @default.
- W4220797271 cites W2010711320 @default.
- W4220797271 cites W2012200796 @default.
- W4220797271 cites W2015509183 @default.
- W4220797271 cites W2017529805 @default.
- W4220797271 cites W2018685233 @default.
- W4220797271 cites W2020057753 @default.
- W4220797271 cites W2030296746 @default.
- W4220797271 cites W2031296359 @default.
- W4220797271 cites W2033992132 @default.
- W4220797271 cites W2038739812 @default.
- W4220797271 cites W2039862949 @default.
- W4220797271 cites W2043803160 @default.
- W4220797271 cites W2046410712 @default.
- W4220797271 cites W2047258328 @default.
- W4220797271 cites W2047531320 @default.
- W4220797271 cites W2049775536 @default.
- W4220797271 cites W2050584193 @default.
- W4220797271 cites W2050676345 @default.
- W4220797271 cites W2052343618 @default.
- W4220797271 cites W2053700561 @default.
- W4220797271 cites W2055166285 @default.
- W4220797271 cites W2059678145 @default.
- W4220797271 cites W2060451852 @default.
- W4220797271 cites W2061879199 @default.
- W4220797271 cites W2062052767 @default.
- W4220797271 cites W2062769503 @default.
- W4220797271 cites W2065911620 @default.
- W4220797271 cites W2067055574 @default.
- W4220797271 cites W2076078539 @default.
- W4220797271 cites W2077814905 @default.
- W4220797271 cites W2079297041 @default.
- W4220797271 cites W2079325727 @default.
- W4220797271 cites W2080614994 @default.
- W4220797271 cites W2081106563 @default.
- W4220797271 cites W2086667723 @default.
- W4220797271 cites W2088413560 @default.
- W4220797271 cites W2088447032 @default.
- W4220797271 cites W2088681154 @default.
- W4220797271 cites W2093425056 @default.
- W4220797271 cites W2099689808 @default.
- W4220797271 cites W2103251397 @default.
- W4220797271 cites W2105184527 @default.
- W4220797271 cites W2105777398 @default.
- W4220797271 cites W2108883802 @default.
- W4220797271 cites W2110646221 @default.
- W4220797271 cites W2115391316 @default.
- W4220797271 cites W2116132301 @default.
- W4220797271 cites W2118748466 @default.
- W4220797271 cites W2122878067 @default.
- W4220797271 cites W2124346611 @default.
- W4220797271 cites W2126425813 @default.
- W4220797271 cites W2127244548 @default.
- W4220797271 cites W2127327054 @default.
- W4220797271 cites W2128039981 @default.
- W4220797271 cites W2131773776 @default.
- W4220797271 cites W2134067282 @default.
- W4220797271 cites W2134604869 @default.
- W4220797271 cites W2134766048 @default.
- W4220797271 cites W2135601420 @default.
- W4220797271 cites W2136082203 @default.
- W4220797271 cites W2137049679 @default.
- W4220797271 cites W2137640850 @default.
- W4220797271 cites W2138152352 @default.
- W4220797271 cites W2138464142 @default.
- W4220797271 cites W2143818728 @default.