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- W4220797863 abstract "The activity of T cells is finely controlled by a set of negative regulators of T-cell antigen receptor (TCR)-mediated signaling. However, how those negative regulators are themselves controlled to prevent ineffective TCR-mediated responses remain poorly understood. Thymocyte-expressed molecule involved in selection (THEMIS) has been characterized over a decade ago as an important player of T cell development. Although the molecular function of THEMIS has long remained puzzling and subject to controversies, latest investigations suggest that THEMIS stimulates TCR-mediated signaling by repressing the tyrosine phosphatases SHP-1 and SHP-2 which exert regulatory function on T cell activation. Recent evidences also point to a role for THEMIS in peripheral T cells beyond its role on thymic selection. Here, we present an overview of the past research on THEMIS in the context of T cell development and peripheral T cell function and discuss the possible implication of THEMIS-based mechanisms on TCR-dependent and independent signaling outcomes." @default.
- W4220797863 created "2022-04-03" @default.
- W4220797863 creator A5008297481 @default.
- W4220797863 creator A5023005855 @default.
- W4220797863 creator A5029555898 @default.
- W4220797863 date "2022-04-01" @default.
- W4220797863 modified "2023-09-30" @default.
- W4220797863 title "Negative times negative equals positive, THEMIS sets the rule on thymic selection and peripheral T cell responses" @default.
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- W4220797863 doi "https://doi.org/10.1016/j.bj.2022.03.008" @default.
- W4220797863 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35346866" @default.
- W4220797863 hasPublicationYear "2022" @default.
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