Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220798645> ?p ?o ?g. }
- W4220798645 endingPage "3816" @default.
- W4220798645 startingPage "3804" @default.
- W4220798645 abstract "In the present study, first, Fe3O4 nanoparticles were functionalized using glutaric acid and then composited with CQDs. Doxorubicin (DOX) drug was loaded to evaluate the performance of the nanocomposite for targeted drug delivery applications. The XRD pattern confirmed the presence of characteristic peaks of CQDs and Fe3O4. In the FTIR spectrum, the presence of carboxyl functional groups on Fe3O4/CQDs was observed; DOX (positive charge) is loaded onto Fe3O4/CQDs (negative charge) by electrostatic absorption. FESEM and AFM images showed that the particle sizes of Fe3O4 and CQDs were 23-75 and 1-3 nm, respectively. The hysteresis curves showed superparamagnetic properties for Fe3O4 and Fe3O4/CQDs (57.3 and 8.4 emu/g). The Fe3O4 hysteresis curve showed superparamagnetic properties (Ms and Mr: 57.3 emu/g and 1.46 emu/g. The loading efficiency and capacity for Fe3O4/CQDs were 93.90% and 37.2 mg DOX/g MNP, respectively. DOX release from Fe3O4/CQDs in PBS showed pH-dependent release behavior where after 70 h at pH 5 and 7.4, about 50 and 21% of DOX were released. Fluorescence images of Fe3O4/CQD-treated cells showed that Fe3O4/CQDs are capable of labeling MCF-7 and HFF cells. Also, T2-weighted MRI scans of Fe3O4/CQDs in water exhibited high r2 relaxivity (86.56 mM-1 S-1). MTT assay showed that DOX-loaded Fe3O4/CQDs are highly biocompatible in contact with HFF cells (viability = 95%), but they kill MCF-7 cancer cells (viability = 45%). Therefore, the synthesized nanocomposite can be used in MRI, targeted drug delivery, and cell labeling." @default.
- W4220798645 created "2022-04-03" @default.
- W4220798645 creator A5012977857 @default.
- W4220798645 creator A5020899796 @default.
- W4220798645 creator A5027147257 @default.
- W4220798645 creator A5053327244 @default.
- W4220798645 creator A5075688961 @default.
- W4220798645 creator A5090226722 @default.
- W4220798645 date "2022-03-16" @default.
- W4220798645 modified "2023-09-23" @default.
- W4220798645 title "In Vitro Study: Synthesis and Evaluation of Fe<sub>3</sub>O<sub>4</sub>/CQD Magnetic/Fluorescent Nanocomposites for Targeted Drug Delivery, MRI, and Cancer Cell Labeling Applications" @default.
- W4220798645 cites W1938215860 @default.
- W4220798645 cites W1992081768 @default.
- W4220798645 cites W1997823973 @default.
- W4220798645 cites W2014241025 @default.
- W4220798645 cites W2014956555 @default.
- W4220798645 cites W2033007989 @default.
- W4220798645 cites W2036215343 @default.
- W4220798645 cites W2048296917 @default.
- W4220798645 cites W2048756703 @default.
- W4220798645 cites W2055073285 @default.
- W4220798645 cites W2060029924 @default.
- W4220798645 cites W2087124630 @default.
- W4220798645 cites W2089257121 @default.
- W4220798645 cites W2108869182 @default.
- W4220798645 cites W2114135715 @default.
- W4220798645 cites W2135155427 @default.
- W4220798645 cites W2158195746 @default.
- W4220798645 cites W2319849582 @default.
- W4220798645 cites W2353990462 @default.
- W4220798645 cites W2478394781 @default.
- W4220798645 cites W2524153263 @default.
- W4220798645 cites W2604841248 @default.
- W4220798645 cites W2617830539 @default.
- W4220798645 cites W2746897718 @default.
- W4220798645 cites W2764226770 @default.
- W4220798645 cites W2787929252 @default.
- W4220798645 cites W2790211976 @default.
- W4220798645 cites W2798163080 @default.
- W4220798645 cites W2799654781 @default.
- W4220798645 cites W2805588674 @default.
- W4220798645 cites W2806904114 @default.
- W4220798645 cites W2886312901 @default.
- W4220798645 cites W2907107547 @default.
- W4220798645 cites W2909488501 @default.
- W4220798645 cites W2941451580 @default.
- W4220798645 cites W2980190521 @default.
- W4220798645 cites W2983691626 @default.
- W4220798645 cites W2998877081 @default.
- W4220798645 cites W3013906970 @default.
- W4220798645 cites W3016750733 @default.
- W4220798645 cites W3042816010 @default.
- W4220798645 cites W3083406893 @default.
- W4220798645 cites W3096191918 @default.
- W4220798645 cites W3096969543 @default.
- W4220798645 cites W3117706574 @default.
- W4220798645 cites W3125034191 @default.
- W4220798645 cites W3133195855 @default.
- W4220798645 cites W3134369759 @default.
- W4220798645 cites W3134683971 @default.
- W4220798645 cites W3186514353 @default.
- W4220798645 cites W3186778132 @default.
- W4220798645 cites W3198320193 @default.
- W4220798645 cites W4206691121 @default.
- W4220798645 cites W4237950581 @default.
- W4220798645 doi "https://doi.org/10.1021/acs.langmuir.1c03458" @default.
- W4220798645 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35294836" @default.
- W4220798645 hasPublicationYear "2022" @default.
- W4220798645 type Work @default.
- W4220798645 citedByCount "11" @default.
- W4220798645 countsByYear W42207986452022 @default.
- W4220798645 countsByYear W42207986452023 @default.
- W4220798645 crossrefType "journal-article" @default.
- W4220798645 hasAuthorship W4220798645A5012977857 @default.
- W4220798645 hasAuthorship W4220798645A5020899796 @default.
- W4220798645 hasAuthorship W4220798645A5027147257 @default.
- W4220798645 hasAuthorship W4220798645A5053327244 @default.
- W4220798645 hasAuthorship W4220798645A5075688961 @default.
- W4220798645 hasAuthorship W4220798645A5090226722 @default.
- W4220798645 hasConcept C115260700 @default.
- W4220798645 hasConcept C121332964 @default.
- W4220798645 hasConcept C123299182 @default.
- W4220798645 hasConcept C127413603 @default.
- W4220798645 hasConcept C13965031 @default.
- W4220798645 hasConcept C141071460 @default.
- W4220798645 hasConcept C155672457 @default.
- W4220798645 hasConcept C171250308 @default.
- W4220798645 hasConcept C185592680 @default.
- W4220798645 hasConcept C192562407 @default.
- W4220798645 hasConcept C202751555 @default.
- W4220798645 hasConcept C23792430 @default.
- W4220798645 hasConcept C2776694085 @default.
- W4220798645 hasConcept C2779820397 @default.
- W4220798645 hasConcept C2780783641 @default.
- W4220798645 hasConcept C2781303535 @default.
- W4220798645 hasConcept C32546565 @default.
- W4220798645 hasConcept C42360764 @default.
- W4220798645 hasConcept C53227056 @default.