Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220798653> ?p ?o ?g. }
- W4220798653 endingPage "91" @default.
- W4220798653 startingPage "77" @default.
- W4220798653 abstract "Aim: This subanalysis of the OPTIPARK study aimed to confirm the effectiveness and safety of opicapone in patients with Parkinson's disease and motor fluctuations in clinical practice specifically in the UK and to assess the impact of opicapone on treatment costs. Methods: Patients received opicapone added to levodopa for 6 months. Clinical outcomes were assessed at 3 and 6 months and treatment costs at 6 months. Results: Most patients' general condition improved at 3 months, with sustained improvements reported at 6 months. Opicapone improved motor and non-motor symptoms at both timepoints, was generally well tolerated and reduced total treatment costs by GBP 3719. Conclusion: Opicapone added to levodopa resulted in clinical improvements and reduced treatment costs across UK clinical practice.Patients with Parkinson's disease (PD) often experience motor fluctuations (reduced and variable response to medication) following prolonged treatment with levodopa, which is currently the most effective treatment for the symptoms of PD. Opicapone has been developed for use in combination with levodopa to reduce the occurrence of motor fluctuations and was shown to be effective in two large clinical trials. This study describes the effectiveness, safety and cost-saving impact of opicapone when used to treat patients with PD and motor fluctuations across everyday clinical practice in the UK. Six months' treatment with opicapone was generally well tolerated, resulted in an improvement of the patients' overall PD condition and reduced treatment costs. Clinical trial registration: Registered in July 2016 at NCT02847442 (ClinicalTrial.gov)." @default.
- W4220798653 created "2022-04-03" @default.
- W4220798653 creator A5001399227 @default.
- W4220798653 creator A5003295739 @default.
- W4220798653 creator A5004351255 @default.
- W4220798653 creator A5021159009 @default.
- W4220798653 creator A5031389008 @default.
- W4220798653 creator A5032235791 @default.
- W4220798653 creator A5036198382 @default.
- W4220798653 creator A5052044853 @default.
- W4220798653 creator A5063335320 @default.
- W4220798653 creator A5077148946 @default.
- W4220798653 creator A5078712323 @default.
- W4220798653 date "2022-04-01" @default.
- W4220798653 modified "2023-10-18" @default.
- W4220798653 title "Opicapone in UK clinical practice: effectiveness, safety and cost analysis in patients with Parkinson's disease" @default.
- W4220798653 cites W1981613318 @default.
- W4220798653 cites W1984655127 @default.
- W4220798653 cites W2000724233 @default.
- W4220798653 cites W2008576914 @default.
- W4220798653 cites W2012942579 @default.
- W4220798653 cites W2036822040 @default.
- W4220798653 cites W2039151038 @default.
- W4220798653 cites W2070947338 @default.
- W4220798653 cites W2084468949 @default.
- W4220798653 cites W2119952655 @default.
- W4220798653 cites W2151599925 @default.
- W4220798653 cites W2156411508 @default.
- W4220798653 cites W2218385786 @default.
- W4220798653 cites W2321110363 @default.
- W4220798653 cites W2562545595 @default.
- W4220798653 cites W2586888004 @default.
- W4220798653 cites W2792548008 @default.
- W4220798653 cites W2794572638 @default.
- W4220798653 cites W2809348882 @default.
- W4220798653 cites W2885650235 @default.
- W4220798653 cites W2892998861 @default.
- W4220798653 cites W2940033607 @default.
- W4220798653 cites W294304874 @default.
- W4220798653 cites W2971545548 @default.
- W4220798653 cites W3011915180 @default.
- W4220798653 cites W3036122209 @default.
- W4220798653 cites W3119205686 @default.
- W4220798653 doi "https://doi.org/10.2217/nmt-2021-0057" @default.
- W4220798653 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35313124" @default.
- W4220798653 hasPublicationYear "2022" @default.
- W4220798653 type Work @default.
- W4220798653 citedByCount "3" @default.
- W4220798653 countsByYear W42207986532022 @default.
- W4220798653 countsByYear W42207986532023 @default.
- W4220798653 crossrefType "journal-article" @default.
- W4220798653 hasAuthorship W4220798653A5001399227 @default.
- W4220798653 hasAuthorship W4220798653A5003295739 @default.
- W4220798653 hasAuthorship W4220798653A5004351255 @default.
- W4220798653 hasAuthorship W4220798653A5021159009 @default.
- W4220798653 hasAuthorship W4220798653A5031389008 @default.
- W4220798653 hasAuthorship W4220798653A5032235791 @default.
- W4220798653 hasAuthorship W4220798653A5036198382 @default.
- W4220798653 hasAuthorship W4220798653A5052044853 @default.
- W4220798653 hasAuthorship W4220798653A5063335320 @default.
- W4220798653 hasAuthorship W4220798653A5077148946 @default.
- W4220798653 hasAuthorship W4220798653A5078712323 @default.
- W4220798653 hasBestOaLocation W42207986531 @default.
- W4220798653 hasConcept C126322002 @default.
- W4220798653 hasConcept C177713679 @default.
- W4220798653 hasConcept C1862650 @default.
- W4220798653 hasConcept C2779134260 @default.
- W4220798653 hasConcept C2779734285 @default.
- W4220798653 hasConcept C2779974597 @default.
- W4220798653 hasConcept C2780304432 @default.
- W4220798653 hasConcept C2780405171 @default.
- W4220798653 hasConcept C535046627 @default.
- W4220798653 hasConcept C71924100 @default.
- W4220798653 hasConceptScore W4220798653C126322002 @default.
- W4220798653 hasConceptScore W4220798653C177713679 @default.
- W4220798653 hasConceptScore W4220798653C1862650 @default.
- W4220798653 hasConceptScore W4220798653C2779134260 @default.
- W4220798653 hasConceptScore W4220798653C2779734285 @default.
- W4220798653 hasConceptScore W4220798653C2779974597 @default.
- W4220798653 hasConceptScore W4220798653C2780304432 @default.
- W4220798653 hasConceptScore W4220798653C2780405171 @default.
- W4220798653 hasConceptScore W4220798653C535046627 @default.
- W4220798653 hasConceptScore W4220798653C71924100 @default.
- W4220798653 hasIssue "2" @default.
- W4220798653 hasLocation W42207986531 @default.
- W4220798653 hasLocation W42207986532 @default.
- W4220798653 hasLocation W42207986533 @default.
- W4220798653 hasLocation W42207986534 @default.
- W4220798653 hasLocation W42207986535 @default.
- W4220798653 hasOpenAccess W4220798653 @default.
- W4220798653 hasPrimaryLocation W42207986531 @default.
- W4220798653 hasRelatedWork W1522308250 @default.
- W4220798653 hasRelatedWork W1900332198 @default.
- W4220798653 hasRelatedWork W2014733789 @default.
- W4220798653 hasRelatedWork W2019422441 @default.
- W4220798653 hasRelatedWork W2231018250 @default.
- W4220798653 hasRelatedWork W2461633631 @default.
- W4220798653 hasRelatedWork W2776279842 @default.