FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220798850> ?p ?o ?g. }

• W4220798850 endingPage "108414" @default.
• W4220798850 startingPage "108414" @default.
• W4220798850 abstract "Somatic cell gene mutations arise in vivo due to replication errors during DNA synthesis occurring spontaneously during normal DNA synthesis or as a result of replication on a DNA template damaged by endogenous or exogenous mutagens. In principle, changes in the frequencies of mutant cells in vivo in humans reflect changes in exposures to exogenous or endogenous DNA damaging insults, other factors being equal. It is becoming increasingly evident however, that somatic mutations in humans have a far greater range of interpretations. For example, mutations in lymphocytes provide invaluable probes for in vivo cellular and molecular processes, providing identification of clonal amplifications of these cells in autoimmune and infectious diseases, transplantation recipients, paroxysmal nocturnal hemoglobinuria (PNH), and cancer. The assay for mutations of the X-chromosomal hypoxanthine guanine phosphoribosyltransferase (HPRT) gene has gained popular acceptance for this purpose since viable mutant cells can be recovered for molecular and other analyses. Although the major application of the HPRT T cell assay remains human population monitoring, the enrichment of activated T cells in the mutant fraction in individuals with ongoing immunological processes has demonstrated the utility of surrogate selection, a method that uses somatic mutation as a surrogate marker for the in vivo T cell proliferation that underlies immunological processes to investigate clinical disorders with immunological features. Studies encompassing a wide range of clinical conditions are reviewed. Despite the historical importance of the HPRT mutation system in validating surrogate selection, there are now additional mutational and other methods for identifying immunologically active T cells. These methods are reviewed and provide insights for strategies to extend surrogate selection in future studies." @default.
• W4220798850 created "2022-04-03" @default.
• W4220798850 creator A5034081251 @default.
• W4220798850 creator A5057395839 @default.
• W4220798850 creator A5058810919 @default.
• W4220798850 creator A5062531155 @default.
• W4220798850 creator A5072759658 @default.
• W4220798850 creator A5091472273 @default.
• W4220798850 date "2022-01-01" @default.
• W4220798850 modified "2023-09-29" @default.
• W4220798850 title "Molecular characterization of hypoxanthine guanine phosphoribosyltransferase mutant T cells in human blood: The concept of surrogate selection for immunologically relevant cells" @default.
• W4220798850 cites W1498172398 @default.
• W4220798850 cites W1498719741 @default.
• W4220798850 cites W1521600055 @default.
• W4220798850 cites W1528875746 @default.
• W4220798850 cites W1541243676 @default.
• W4220798850 cites W1556986935 @default.
• W4220798850 cites W1580831787 @default.
• W4220798850 cites W1590537765 @default.
• W4220798850 cites W1602799572 @default.
• W4220798850 cites W1893868216 @default.
• W4220798850 cites W1952278424 @default.
• W4220798850 cites W1952707316 @default.
• W4220798850 cites W1963522243 @default.
• W4220798850 cites W1966594791 @default.
• W4220798850 cites W1970218284 @default.
• W4220798850 cites W1971516038 @default.
• W4220798850 cites W1973639800 @default.
• W4220798850 cites W1976503125 @default.
• W4220798850 cites W1976785499 @default.
• W4220798850 cites W1978518799 @default.
• W4220798850 cites W1978700432 @default.
• W4220798850 cites W1981480494 @default.
• W4220798850 cites W1988814431 @default.
• W4220798850 cites W1989492053 @default.
• W4220798850 cites W1996383704 @default.
• W4220798850 cites W1997562641 @default.
• W4220798850 cites W2000330349 @default.
• W4220798850 cites W2001989329 @default.
• W4220798850 cites W2005529866 @default.
• W4220798850 cites W2007890930 @default.
• W4220798850 cites W2008086119 @default.
• W4220798850 cites W2008180326 @default.
• W4220798850 cites W2010232873 @default.
• W4220798850 cites W2012927708 @default.
• W4220798850 cites W2014513599 @default.
• W4220798850 cites W2015888836 @default.
• W4220798850 cites W2018214157 @default.
• W4220798850 cites W2019552331 @default.
• W4220798850 cites W2020110300 @default.
• W4220798850 cites W2020843599 @default.
• W4220798850 cites W2021920796 @default.
• W4220798850 cites W2023014440 @default.
• W4220798850 cites W2023411218 @default.
• W4220798850 cites W2024410915 @default.
• W4220798850 cites W2024423150 @default.
• W4220798850 cites W2024748688 @default.
• W4220798850 cites W2027776732 @default.
• W4220798850 cites W2029567705 @default.
• W4220798850 cites W2029680253 @default.
• W4220798850 cites W2030306045 @default.
• W4220798850 cites W2033505817 @default.
• W4220798850 cites W2035870702 @default.
• W4220798850 cites W2038251476 @default.
• W4220798850 cites W2039347022 @default.
• W4220798850 cites W2041677964 @default.
• W4220798850 cites W2044560758 @default.
• W4220798850 cites W2046775765 @default.
• W4220798850 cites W2050333584 @default.
• W4220798850 cites W2050606799 @default.
• W4220798850 cites W2051771279 @default.
• W4220798850 cites W2063230624 @default.
• W4220798850 cites W2067069532 @default.
• W4220798850 cites W2069043306 @default.
• W4220798850 cites W2070649644 @default.
• W4220798850 cites W2071240072 @default.
• W4220798850 cites W2072044767 @default.
• W4220798850 cites W2074918485 @default.
• W4220798850 cites W2084620046 @default.
• W4220798850 cites W2084748398 @default.
• W4220798850 cites W2085117199 @default.
• W4220798850 cites W2089408703 @default.
• W4220798850 cites W2090034860 @default.
• W4220798850 cites W2096760065 @default.
• W4220798850 cites W2097007458 @default.
• W4220798850 cites W2097289038 @default.
• W4220798850 cites W2097664721 @default.
• W4220798850 cites W2098454110 @default.
• W4220798850 cites W2102212449 @default.
• W4220798850 cites W2103849447 @default.
• W4220798850 cites W2105896951 @default.
• W4220798850 cites W2111315591 @default.
• W4220798850 cites W2129876916 @default.
• W4220798850 cites W2131748930 @default.
• W4220798850 cites W2133299991 @default.
• W4220798850 cites W2134302830 @default.
• W4220798850 cites W2135228368 @default.
• W4220798850 cites W2135937351 @default.

• next