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• W4220802185 abstract "We explore the combined effect of the intrinsic noise and time delay on the spatial pattern formation within the framework of a multi-scale mobile lattice model mimicking two-dimensional epithelium tissues. Every cell is represented by an elastic polygon changing its form and size under pressure from the surrounding cells. The model includes the procedure of minimization of the potential energy of tissue. The protein fluctuations in the tissue are driven by transcription/translation processes in epithelial cells exchanging chemical and mechanical signals. Network architecture includes a simple autorepressor model with time-delayed negative feedback, in which the only gene defines the oscillatory activity. Simultaneously, the expressed protein of the autorepressor acts as a positive regulator of the signaling protein by activating its transcription. The signaling species is assumed to spread from one cell to the other by the diffusion mechanism. We provide both deterministic and stochastic descriptions. The numerical simulation of spatially-extended stochastic oscillations is performed using a generalized Gillespie algorithm. We developed this method earlier to account for the non-Markovian properties of random biochemical events with delay. Finally, we demonstrate that time delay, intrinsic noise, and spatial signaling can cause a system to develop the protein pattern even when its deterministic counterpart exhibits no pattern formation." @default.
• W4220802185 created "2022-04-03" @default.
• W4220802185 creator A5017334581 @default.
• W4220802185 date "2022-01-01" @default.
• W4220802185 modified "2023-10-14" @default.
• W4220802185 title "Protein pattern formation induced by the joint effect of noise and delay in a multi-cellular system" @default.
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• W4220802185 doi "https://doi.org/10.1051/mmnp/2022011" @default.
• W4220802185 hasPublicationYear "2022" @default.
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