FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220803213> ?p ?o ?g. }

• W4220803213 endingPage "6837" @default.
• W4220803213 startingPage "6818" @default.
• W4220803213 abstract "The purpose of this research was to explore the diagnostic/prognostic significance and prospective molecular mechanisms of mitogen-activated protein kinase kinase kinases (MAP3Ks) in hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). Diagnostic/prognostic significance of MAP3Ks was screened in the GSE1450 data set and validated in the Guangxi cohort. Various bioinformatics tools were used to explore the biological functions of prognosis-related genes. Subsequently, molecular biology assays were used to verify the biological functions and molecular mechanisms of specific gene. MAP3K9 was observed to be differentially expressed in HCC and adjacent tissues with satisfactory diagnostic value. It was discovered in survival analysis that MAP3K13 and MAP3K15 were associated with overall survival (OS) of patients with HBV-related HCC in the GSE1450 data set and the Guangxi cohort. Nomograms were established based on prognosis-related genes and clinical factors for individualized risk assessment. The assays on HCC cells demonstrated that MAP3K13 regulated the death and proliferation of HCC cells by activating the JNK pathway and inducing the expression of apoptosis-related factors. In conclusion, our results suggested that MAP3K9 might serve as a diagnostic biomarker in HBV-related HCC and MAP3K13 and MAP3K15 might serve as useful prognostic biomarkers. Besides, cytological assays prompted that MAP3K13 might impact the prognosis of HCC by regulating the JNK pathway and inducing apoptosis." @default.
• W4220803213 created "2022-04-03" @default.
• W4220803213 creator A5000436077 @default.
• W4220803213 creator A5004568307 @default.
• W4220803213 creator A5010154803 @default.
• W4220803213 creator A5037176979 @default.
• W4220803213 creator A5079417175 @default.
• W4220803213 creator A5086083806 @default.
• W4220803213 creator A5088777647 @default.
• W4220803213 date "2022-03-01" @default.
• W4220803213 modified "2023-09-26" @default.
• W4220803213 title "Clinical significance of mitogen-activated protein kinase kinase kinases in hepatitis B virus -related hepatocellular carcinoma and underlying mechanism exploration" @default.
• W4220803213 cites W1934377097 @default.
• W4220803213 cites W1965571714 @default.
• W4220803213 cites W1970767712 @default.
• W4220803213 cites W1972638272 @default.
• W4220803213 cites W1973839195 @default.
• W4220803213 cites W1996405087 @default.
• W4220803213 cites W1998809668 @default.
• W4220803213 cites W2018838463 @default.
• W4220803213 cites W2018851752 @default.
• W4220803213 cites W2019023506 @default.
• W4220803213 cites W2022928390 @default.
• W4220803213 cites W2025706879 @default.
• W4220803213 cites W2040357332 @default.
• W4220803213 cites W2052289997 @default.
• W4220803213 cites W2074441554 @default.
• W4220803213 cites W2088894802 @default.
• W4220803213 cites W2091415498 @default.
• W4220803213 cites W2093260830 @default.
• W4220803213 cites W2107168679 @default.
• W4220803213 cites W2107495112 @default.
• W4220803213 cites W2109242212 @default.
• W4220803213 cites W2122683221 @default.
• W4220803213 cites W2133425503 @default.
• W4220803213 cites W2133801172 @default.
• W4220803213 cites W2134511480 @default.
• W4220803213 cites W2136828732 @default.
• W4220803213 cites W2154239359 @default.
• W4220803213 cites W2158217645 @default.
• W4220803213 cites W2164241627 @default.
• W4220803213 cites W2272984102 @default.
• W4220803213 cites W2294765885 @default.
• W4220803213 cites W2326245412 @default.
• W4220803213 cites W2341442578 @default.
• W4220803213 cites W2404013489 @default.
• W4220803213 cites W2578043809 @default.
• W4220803213 cites W2609054329 @default.
• W4220803213 cites W2741325805 @default.
• W4220803213 cites W2755839585 @default.
• W4220803213 cites W2759937899 @default.
• W4220803213 cites W2761031851 @default.
• W4220803213 cites W2790805946 @default.
• W4220803213 cites W2796494016 @default.
• W4220803213 cites W2805412467 @default.
• W4220803213 cites W2810459274 @default.
• W4220803213 cites W2888779330 @default.
• W4220803213 cites W2889646458 @default.
• W4220803213 cites W2899084160 @default.
• W4220803213 cites W2951907144 @default.
• W4220803213 cites W2960366186 @default.
• W4220803213 cites W3107330415 @default.
• W4220803213 cites W3113537259 @default.
• W4220803213 cites W3116501810 @default.
• W4220803213 cites W3119902648 @default.
• W4220803213 doi "https://doi.org/10.1080/21655979.2022.2037224" @default.
• W4220803213 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35311629" @default.
• W4220803213 hasPublicationYear "2022" @default.
• W4220803213 type Work @default.
• W4220803213 citedByCount "0" @default.
• W4220803213 crossrefType "journal-article" @default.
• W4220803213 hasAuthorship W4220803213A5000436077 @default.
• W4220803213 hasAuthorship W4220803213A5004568307 @default.
• W4220803213 hasAuthorship W4220803213A5010154803 @default.
• W4220803213 hasAuthorship W4220803213A5037176979 @default.
• W4220803213 hasAuthorship W4220803213A5079417175 @default.
• W4220803213 hasAuthorship W4220803213A5086083806 @default.
• W4220803213 hasAuthorship W4220803213A5088777647 @default.
• W4220803213 hasBestOaLocation W42208032131 @default.
• W4220803213 hasConcept C111472728 @default.
• W4220803213 hasConcept C138885662 @default.
• W4220803213 hasConcept C143998085 @default.
• W4220803213 hasConcept C184235292 @default.
• W4220803213 hasConcept C190283241 @default.
• W4220803213 hasConcept C203014093 @default.
• W4220803213 hasConcept C2522874641 @default.
• W4220803213 hasConcept C2778019345 @default.
• W4220803213 hasConcept C2780593183 @default.
• W4220803213 hasConcept C2781197716 @default.
• W4220803213 hasConcept C502942594 @default.
• W4220803213 hasConcept C54355233 @default.
• W4220803213 hasConcept C60644358 @default.
• W4220803213 hasConcept C71924100 @default.
• W4220803213 hasConcept C86803240 @default.
• W4220803213 hasConcept C89611455 @default.
• W4220803213 hasConcept C97029542 @default.
• W4220803213 hasConceptScore W4220803213C111472728 @default.
• W4220803213 hasConceptScore W4220803213C138885662 @default.

• next