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- W4220803224 endingPage "1292" @default.
- W4220803224 startingPage "1292" @default.
- W4220803224 abstract "Obesity, type 2 diabetes, and their associated comorbidities impact brain metabolism and function and constitute risk factors for cognitive impairment. Alterations to taurine homeostasis can impact a number of biological processes, such as osmolarity control, calcium homeostasis, and inhibitory neurotransmission, and have been reported in both metabolic and neurodegenerative disorders. Models of neurodegenerative disorders show reduced brain taurine concentrations. On the other hand, models of insulin-dependent diabetes, insulin resistance, and diet-induced obesity display taurine accumulation in the hippocampus. Given the possible cytoprotective actions of taurine, such cerebral accumulation of taurine might constitute a compensatory mechanism that attempts to prevent neurodegeneration. The present article provides an overview of brain taurine homeostasis and reviews the mechanisms by which taurine can afford neuroprotection in individuals with obesity and diabetes. We conclude that further research is needed for understanding taurine homeostasis in metabolic disorders with an impact on brain function." @default.
- W4220803224 created "2022-04-03" @default.
- W4220803224 creator A5009436830 @default.
- W4220803224 creator A5034600497 @default.
- W4220803224 creator A5083807092 @default.
- W4220803224 date "2022-03-18" @default.
- W4220803224 modified "2023-10-18" @default.
- W4220803224 title "Taurine Supplementation as a Neuroprotective Strategy upon Brain Dysfunction in Metabolic Syndrome and Diabetes" @default.
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