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• W4220803640 endingPage "112862" @default.
• W4220803640 startingPage "112862" @default.
• W4220803640 abstract "Bioactive phytochemicals from natural source have gained tremendous interest over several decades due to their wide and diverse therapeutic activities playing key role as functional food supplements, pharmaceutical and nutraceutical products. Nevertheless, their application as therapeutically active moieties and formulation into novel drug delivery systems are hindered due to major drawbacks such as poor solubility, bioavailability and dissolution rate and instability contributing to reduction in bioactivity. These drawbacks can be effectively overcome by their complexation with different cyclodextrins. Present article discusses complexation of phytochemicals varying from flavonoids, phenolics, triterpenes, and tropolone with different natural and synthetic cyclodextrins. Moreover, the article summarizes complexation methods, complexation efficiency, stability, stability constants and enhancement in rate and extent of dissolution, bioavailability, solubility, in vivo and in vitro activities of reported complexed phytochemicals. Additionally, the article presents update of published patent details comprising of complexed phytochemicals of therapeutic significance. Thus, phytochemical cyclodextrin complexes have tremendous potential for transformation into drug delivery systems as substantiated by significant outcome of research findings." @default.
• W4220803640 created "2022-04-03" @default.
• W4220803640 creator A5019230268 @default.
• W4220803640 creator A5054364889 @default.
• W4220803640 creator A5059344362 @default.
• W4220803640 creator A5085541110 @default.
• W4220803640 date "2022-05-01" @default.
• W4220803640 modified "2023-10-18" @default.
• W4220803640 title "Complexation of phytochemicals with cyclodextrins and their derivatives- an update" @default.
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