FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220804543> ?p ?o ?g. }

• W4220804543 endingPage "e004421" @default.
• W4220804543 startingPage "e004421" @default.
• W4220804543 abstract "Background In patients receiving immune checkpoint inhibitor (ICI) therapy, acute kidney injury (AKI) is common, and can occur either from kidney injury unrelated to ICI use or from immune activation resulting in acute interstitial nephritis (AIN). In this study, we test the hypothesis that occurrence of AIN indicates a favorable treatment response to ICI therapy and therefore among patients who develop AKI while on ICI therapy, those with AIN will demonstrate greater survival compared with others with AKI. Methods In this observational cohort study, we included participants initiated on ICI therapy between 2013 and 2019. We tested the independent association of AKI and estimated AIN (eAIN) with mortality up to 1 year after therapy initiation as compared with those without AKI using time-varying Cox proportional hazard models controlling for demographics, comorbidities, cancer type, stage, and therapy, and baseline laboratory values. We defined eAIN as those with a predicted probability of AIN >90th percentile derived from a recently validated diagnostic model. Results Of 2207 patients initiated on ICIs, 617 (28%) died at 1 year and 549 (25%) developed AKI. AKI was independently associated with higher mortality (adjusted HR, 2.28 (95% CI 1.90 to 2.72)). Those AKI patients with eAIN had more severe AKI as reflected by a higher peak serum creatinine (3.3 (IQR 2.1–6.1) vs 1.4 (1.2–1.9) mg/dL, p<0.001) but exhibited lower mortality than those without eAIN in univariable analysis (HR 0.43 (95% CI 0.21 to 0.89)) and after adjusting for demographics, comorbidities, and cancer type and severity (adjusted HR 0.44 (95% CI 0.21 to 0.93)). Conclusion In patients treated with ICI, mortality was higher in those with AKI unrelated to ICI but lower in those where the underlying etiology was AIN. Future studies could evaluate the association of biopsy-proven or biomarker-proven AIN with mortality in those receiving ICI therapy." @default.
• W4220804543 created "2022-04-03" @default.
• W4220804543 creator A5001175430 @default.
• W4220804543 creator A5004446387 @default.
• W4220804543 creator A5005836117 @default.
• W4220804543 creator A5013988879 @default.
• W4220804543 creator A5023587190 @default.
• W4220804543 creator A5024249077 @default.
• W4220804543 creator A5024920902 @default.
• W4220804543 creator A5043430229 @default.
• W4220804543 creator A5051276161 @default.
• W4220804543 creator A5053033023 @default.
• W4220804543 creator A5053840136 @default.
• W4220804543 creator A5059533310 @default.
• W4220804543 creator A5069568894 @default.
• W4220804543 creator A5090821229 @default.
• W4220804543 date "2022-03-01" @default.
• W4220804543 modified "2023-10-18" @default.
• W4220804543 title "Mortality after acute kidney injury and acute interstitial nephritis in patients prescribed immune checkpoint inhibitor therapy" @default.
• W4220804543 cites W2058323747 @default.
• W4220804543 cites W2072295095 @default.
• W4220804543 cites W2140678380 @default.
• W4220804543 cites W2153942285 @default.
• W4220804543 cites W2167501720 @default.
• W4220804543 cites W2179179825 @default.
• W4220804543 cites W2314258949 @default.
• W4220804543 cites W2413514895 @default.
• W4220804543 cites W2572174216 @default.
• W4220804543 cites W2600124489 @default.
• W4220804543 cites W2754877046 @default.
• W4220804543 cites W2759963646 @default.
• W4220804543 cites W2770404972 @default.
• W4220804543 cites W2778853238 @default.
• W4220804543 cites W2791483720 @default.
• W4220804543 cites W2801738147 @default.
• W4220804543 cites W2809615201 @default.
• W4220804543 cites W2809773917 @default.
• W4220804543 cites W2810821243 @default.
• W4220804543 cites W2896274372 @default.
• W4220804543 cites W2897483443 @default.
• W4220804543 cites W2903486314 @default.
• W4220804543 cites W2905314444 @default.
• W4220804543 cites W2910268554 @default.
• W4220804543 cites W2914287567 @default.
• W4220804543 cites W2945207519 @default.
• W4220804543 cites W2952762910 @default.
• W4220804543 cites W2960130441 @default.
• W4220804543 cites W2969665548 @default.
• W4220804543 cites W2976964237 @default.
• W4220804543 cites W2984413960 @default.
• W4220804543 cites W2988124258 @default.
• W4220804543 cites W2997561837 @default.
• W4220804543 cites W3000259466 @default.
• W4220804543 cites W3001173873 @default.
• W4220804543 cites W3004284786 @default.
• W4220804543 cites W3006479182 @default.
• W4220804543 cites W3022186633 @default.
• W4220804543 cites W3037575240 @default.
• W4220804543 cites W3092943233 @default.
• W4220804543 cites W3093379187 @default.
• W4220804543 cites W3096976558 @default.
• W4220804543 cites W3120233339 @default.
• W4220804543 cites W3128154224 @default.
• W4220804543 cites W3130288202 @default.
• W4220804543 cites W3134503278 @default.
• W4220804543 cites W3155812430 @default.
• W4220804543 cites W3202872245 @default.
• W4220804543 cites W4200341860 @default.
• W4220804543 cites W4205572254 @default.
• W4220804543 cites W4234372988 @default.
• W4220804543 doi "https://doi.org/10.1136/jitc-2021-004421" @default.
• W4220804543 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35354588" @default.
• W4220804543 hasPublicationYear "2022" @default.
• W4220804543 type Work @default.
• W4220804543 citedByCount "15" @default.
• W4220804543 countsByYear W42208045432022 @default.
• W4220804543 countsByYear W42208045432023 @default.
• W4220804543 crossrefType "journal-article" @default.
• W4220804543 hasAuthorship W4220804543A5001175430 @default.
• W4220804543 hasAuthorship W4220804543A5004446387 @default.
• W4220804543 hasAuthorship W4220804543A5005836117 @default.
• W4220804543 hasAuthorship W4220804543A5013988879 @default.
• W4220804543 hasAuthorship W4220804543A5023587190 @default.
• W4220804543 hasAuthorship W4220804543A5024249077 @default.
• W4220804543 hasAuthorship W4220804543A5024920902 @default.
• W4220804543 hasAuthorship W4220804543A5043430229 @default.
• W4220804543 hasAuthorship W4220804543A5051276161 @default.
• W4220804543 hasAuthorship W4220804543A5053033023 @default.
• W4220804543 hasAuthorship W4220804543A5053840136 @default.
• W4220804543 hasAuthorship W4220804543A5059533310 @default.
• W4220804543 hasAuthorship W4220804543A5069568894 @default.
• W4220804543 hasAuthorship W4220804543A5090821229 @default.
• W4220804543 hasBestOaLocation W42208045431 @default.
• W4220804543 hasConcept C126322002 @default.
• W4220804543 hasConcept C159641895 @default.
• W4220804543 hasConcept C166957645 @default.
• W4220804543 hasConcept C207103383 @default.
• W4220804543 hasConcept C2777051993 @default.

• next