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- W4220804710 abstract "Cardiotoxicity is a relatively frequent and potentially serious side effect of traditional and targeted cancer therapies. Both general measures and specific pharmacologic cardioprotective interventions as well as imaging- and biomarker-based surveillance strategies to identify patients at high risk have been tested in randomized controlled trials to prevent or attenuate cancer therapy–related cardiotoxic effects. Although meta-analyses including early trials suggest an overall beneficial effect, there is substantial heterogeneity in results. Recent randomized controlled trials of neurohormonal inhibitors in patients receiving anthracyclines and/or human epidermal growth factor receptor 2–targeted therapies have shown a lower rate of cancer therapy–related cardiac dysfunction than previously reported and a modest or no sustained effect of the interventions. Data on preventive cardioprotective strategies for novel cancer drugs are lacking. Larger, prospective multicenter randomized clinical trials testing traditional and novel interventions are required to more accurately define the benefit of different cardioprotective strategies and to refine risk prediction and identify patients who are likely to benefit." @default.
- W4220804710 created "2022-04-03" @default.
- W4220804710 creator A5003370460 @default.
- W4220804710 creator A5007538598 @default.
- W4220804710 creator A5091747004 @default.
- W4220804710 date "2022-03-01" @default.
- W4220804710 modified "2023-10-09" @default.
- W4220804710 title "The Role of Cardioprotection in Cancer Therapy Cardiotoxicity" @default.
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- W4220804710 doi "https://doi.org/10.1016/j.jaccao.2022.01.101" @default.
- W4220804710 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35492815" @default.
- W4220804710 hasPublicationYear "2022" @default.
- W4220804710 type Work @default.