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• W4220804802 abstract "• In C57BL/6J mice, corticosterone excess reduced 11β HSD-1 mRNA in the hippocampus and liver and increased that in fat. • In CRH transgenic mice, 11β HSD-1 mRNA decreased in the hippocampus and liver and increased in fat. • Removal of glucocorticoid excess by adrenalectomy in CRH transgenic mice restored these changes in 11β HSD-1 mRNA. • The significance of tissue-specific regulation of 11β HSD-1 by glucocorticoid excess needs to be clarified in the future. The 11β hydroxysteroid dehydrogenase type-1 (11βHSD-1) is a predominant 11β-reductase regenerating bioactive glucocorticoids (cortisol, corticosterone) from inactive 11-keto forms (cortisone, dehydrocorticosterone), expressed mainly in the brain, liver and adipose tissue. Although the expression levels of 11β HSD-1 mRNA are known to be influenced by glucocorticoids, its tissue-specific regulation is not completely elucidated. In this study, we examined the effect of persistent glucocorticoid excess on the expression of 11β HSD-1 mRNA in the hippocampus, liver, and abdominal adipose tissue in vivo using quantitative real-time PCR. We found that, in C57BL/6J mice treated with corticosterone (CORT) pellet for 2 weeks, 11β HSD-1 mRNA decreased in the hippocampus (HIPP) and liver, whereas it increased in the abdominal fat (FAT), compared with placebo treatment [HIPP: placebo 1.00 ± 0.14, CORT 0.63 ± 0.04; liver: placebo 1.00 ± 0.08, CORT 0.73 ± 0.06; FAT: placebo 1.00 ± 0.16, CORT 2.26 ± 0.39]. Moreover, in CRH transgenic mice, an animal model of Cushing’s syndrome with high plasma CORT level, 11β HSD-1 mRNA was also decreased in the hippocampus and liver, and increased in the abdominal adipose tissue compared to that in wild-type mice. These changes were reversed after adrenalectomy in CRH-Tg mice. Altogether, these results reveal the differential regulation of 11β HSD-1 mRNA by glucocorticoid among the tissues examined." @default.
• W4220804802 created "2022-04-03" @default.
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• W4220804802 date "2022-07-01" @default.
• W4220804802 modified "2023-09-29" @default.
• W4220804802 title "Tissue-specific regulation of 11β hydroxysteroid dehydrogenase type-1 mRNA expressions in Cushing’s syndrome mouse model" @default.
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• W4220804802 doi "https://doi.org/10.1016/j.steroids.2022.109021" @default.
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