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- W4220807009 abstract "Abstract Cerebral ischemia is an important factor in developing neurological damage without appropriate medical treatment. Kombucha tea(KT) is a fermented beverage that produces many compounds with antioxidant power with potential health effects. This study was performed to evaluate the effect of pre-treatment of kombucha tea on brain edema, neurobehavioral, and oxidative stress in the global brain ischemia model. Adult male Wistar rats were divided into four groups include; the sham, the ischemic, and the KT-treated-ischemic groups. KT was administrated two weeks before inducing transient global cerebral ischemia at two different dosages (one and two ml/kg/day, gavage). The global brain ischemia was induced by blocking the common carotid arteries for one hour, followed by 24 hours of reperfusion. At the end of reperfusion, neurobehavioral studies were done. Brain edema was determined by dry-wet methods. Malondialdehyde (MDA), total antioxidant capacity (TAC), glutathione peroxidase (GPx), superoxide dismutase (SOD), and catalase (CAT) levels were measured in the serum and the brain tissue. Our results showed that pre-treatment of KT significantly reduced brain edema and MDA levels in the blood and the brain. It significantly increased the total TAC and GPx levels in the blood and the brain in ischemic rats treated with KT. The CAT activity significantly increased in the blood, but it didn’t significantly change the brain. KT of pre-treatment significantly ameliorated neurobehavioral defects in the ischemic rats. Our data demonstrated that pre-treatment of KT maybe protect the brain against ischemic-reperfusion injury through a decrease in the production of lipid peroxidation and an increase in the capacity of antioxidants defense." @default.
- W4220807009 created "2022-04-03" @default.
- W4220807009 creator A5041309592 @default.
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- W4220807009 date "2022-03-29" @default.
- W4220807009 modified "2023-10-16" @default.
- W4220807009 title "Chronic Pre-Treatment of Kombucha Tea Protects Brain Injury induced by Ischemia/Reperfusion in Global Brain Ischemia" @default.
- W4220807009 doi "https://doi.org/10.21203/rs.3.rs-1482869/v1" @default.
- W4220807009 hasPublicationYear "2022" @default.
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