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- W4220807592 abstract "Abstract Brain rhythms are strongly linked with behavior, and abnormal rhythms can signify pathophysiology. For instance, the basal ganglia exhibit a wide range of low-frequency oscillations during movement, but pathological “beta” rhythms at ~ 20 Hz have been observed in Parkinson’s disease (PD) and in PD animal models. All brain rhythms have a frequency, which describes how often they oscillate, and a phase, which describes the precise time that peaks and troughs of brain rhythms occur. Although frequency has been extensively studied, the relevance of phase is unknown, in part because it is difficult to causally manipulate the instantaneous phase of ongoing brain rhythms. Here, we developed a phase-adaptive, real-time, closed-loop algorithm to deliver optogenetic stimulation at a specific phase with millisecond latency. We combined this P hase- A daptive B rain ST imulation (PABST) approach with cell-type-specific optogenetic methods to stimulate basal ganglia networks in dopamine-depleted mice that model motor aspects of human PD. We focused on striatal medium spiny neurons expressing D1-type dopamine receptors because these neurons can facilitate movement. We report three main results. First, we found that our approach delivered PABST within system latencies of 13 milliseconds. Second, we report that closed-loop stimulation powerfully influenced the spike-field coherence of local brain rhythms within the dorsal striatum. Finally, we found that 4-Hz, but not 20-Hz, PABST improved movement speed by 41%. These data provide causal evidence that phase is relevant for brain stimulation, which will allow for more precise, targeted, and individualized brain stimulation. Our findings are applicable to a broad range of preclinical brain stimulation approaches and could also inform circuit-specific neuromodulation treatments for human brain disease." @default.
- W4220807592 created "2022-04-03" @default.
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- W4220807592 date "2022-03-09" @default.
- W4220807592 modified "2023-09-23" @default.
- W4220807592 title "Phase-adaptive Brain Stimulation of Striatal D1 Medium Spiny Neurons" @default.
- W4220807592 doi "https://doi.org/10.21203/rs.3.rs-1390088/v1" @default.
- W4220807592 hasPublicationYear "2022" @default.
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