Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220807614> ?p ?o ?g. }
- W4220807614 abstract "Controlled human infection models (CHIMs) have provided pivotal scientific advancements, contributing to the licensure of new vaccines for many pathogens. Despite being one of the world's oldest known pathogens, there are still significant gaps in our knowledge surrounding the immunobiology of Mycobacterium tuberculosis (M. tb). Furthermore, the only licensed vaccine, BCG, is a century old and demonstrates limited efficacy in adults from endemic areas. Despite good global uptake of BCG, tuberculosis (TB) remains a silent epidemic killing 1.4 million in 2019 (WHO, Global tuberculosis report 2020). A mycobacterial CHIM could expedite the development pipeline of novel TB vaccines and provide critical understanding on the immune response to TB. However, developing a CHIM for such a complex organism is a challenging process. The first hurdle to address is which challenge agent to use, as it would not be ethical to use virulent M. tb. This chapter describes the current progress and outstanding issues in the development of a TB CHIM. Previous and current human studies include both aerosol and intradermal models using either BCG or purified protein derivative (PPD) as a surrogate agent. Future work investigating the use of attenuated M. tb is underway." @default.
- W4220807614 created "2022-04-03" @default.
- W4220807614 creator A5048219414 @default.
- W4220807614 creator A5082085590 @default.
- W4220807614 date "2022-01-01" @default.
- W4220807614 modified "2023-09-26" @default.
- W4220807614 title "Challenges in Developing a Controlled Human Tuberculosis Challenge Model" @default.
- W4220807614 cites W1546213590 @default.
- W4220807614 cites W1920434477 @default.
- W4220807614 cites W1969623044 @default.
- W4220807614 cites W1983763479 @default.
- W4220807614 cites W1984118999 @default.
- W4220807614 cites W1985004048 @default.
- W4220807614 cites W1992186914 @default.
- W4220807614 cites W2002916173 @default.
- W4220807614 cites W2004604338 @default.
- W4220807614 cites W2006165959 @default.
- W4220807614 cites W2011838261 @default.
- W4220807614 cites W2023284037 @default.
- W4220807614 cites W2024974612 @default.
- W4220807614 cites W2026247118 @default.
- W4220807614 cites W2033193372 @default.
- W4220807614 cites W2042814843 @default.
- W4220807614 cites W2050862002 @default.
- W4220807614 cites W2066091327 @default.
- W4220807614 cites W2073311979 @default.
- W4220807614 cites W2075477269 @default.
- W4220807614 cites W2075647477 @default.
- W4220807614 cites W2078688899 @default.
- W4220807614 cites W2086707243 @default.
- W4220807614 cites W2093423705 @default.
- W4220807614 cites W2097103917 @default.
- W4220807614 cites W2097340122 @default.
- W4220807614 cites W2100136451 @default.
- W4220807614 cites W2106942635 @default.
- W4220807614 cites W2107717593 @default.
- W4220807614 cites W2108723412 @default.
- W4220807614 cites W2110531991 @default.
- W4220807614 cites W2112210766 @default.
- W4220807614 cites W2114790458 @default.
- W4220807614 cites W2123114485 @default.
- W4220807614 cites W2124515177 @default.
- W4220807614 cites W2129996072 @default.
- W4220807614 cites W2133562534 @default.
- W4220807614 cites W2137633461 @default.
- W4220807614 cites W2141922592 @default.
- W4220807614 cites W2143025016 @default.
- W4220807614 cites W2143455217 @default.
- W4220807614 cites W2144331211 @default.
- W4220807614 cites W2157417623 @default.
- W4220807614 cites W2157950610 @default.
- W4220807614 cites W2158023121 @default.
- W4220807614 cites W2158101883 @default.
- W4220807614 cites W2161897199 @default.
- W4220807614 cites W2163861382 @default.
- W4220807614 cites W2164988748 @default.
- W4220807614 cites W2173624599 @default.
- W4220807614 cites W2176522783 @default.
- W4220807614 cites W2309663145 @default.
- W4220807614 cites W2410912397 @default.
- W4220807614 cites W2521361619 @default.
- W4220807614 cites W2556974178 @default.
- W4220807614 cites W2562505886 @default.
- W4220807614 cites W2615024843 @default.
- W4220807614 cites W2752890220 @default.
- W4220807614 cites W2769979750 @default.
- W4220807614 cites W2783006274 @default.
- W4220807614 cites W2808888611 @default.
- W4220807614 cites W2872754763 @default.
- W4220807614 cites W2886389863 @default.
- W4220807614 cites W2919874306 @default.
- W4220807614 cites W2926740022 @default.
- W4220807614 cites W2947001639 @default.
- W4220807614 cites W2967169190 @default.
- W4220807614 cites W2982353502 @default.
- W4220807614 cites W2983938700 @default.
- W4220807614 cites W2994733021 @default.
- W4220807614 cites W3004157864 @default.
- W4220807614 cites W3008522998 @default.
- W4220807614 cites W3011610724 @default.
- W4220807614 cites W3082813361 @default.
- W4220807614 cites W3095665120 @default.
- W4220807614 cites W3136333042 @default.
- W4220807614 cites W3159597664 @default.
- W4220807614 cites W4242401426 @default.
- W4220807614 cites W926099720 @default.
- W4220807614 doi "https://doi.org/10.1007/82_2022_252" @default.
- W4220807614 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35332386" @default.
- W4220807614 hasPublicationYear "2022" @default.
- W4220807614 type Work @default.
- W4220807614 citedByCount "1" @default.
- W4220807614 countsByYear W42208076142023 @default.
- W4220807614 crossrefType "book-chapter" @default.
- W4220807614 hasAuthorship W4220807614A5048219414 @default.
- W4220807614 hasAuthorship W4220807614A5082085590 @default.
- W4220807614 hasConcept C138816342 @default.
- W4220807614 hasConcept C142724271 @default.
- W4220807614 hasConcept C159047783 @default.
- W4220807614 hasConcept C159110408 @default.
- W4220807614 hasConcept C17744445 @default.