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- W4220808568 endingPage "1660" @default.
- W4220808568 startingPage "1607" @default.
- W4220808568 abstract "The key proteins involved in transcriptional regulation play convergent roles in cellular homeostasis, and their dysfunction mediates aberrant gene expressions that underline the hallmarks of tumorigenesis. As tumor progression is dependent on such abnormal regulation of transcription, it is important to discover novel chemical entities as antitumor drugs that target key tumor-associated proteins involved in transcriptional regulation. Despite most key proteins (especially transcription factors) involved in transcriptional regulation are historically recognized as undruggable targets, multiple targeting approaches at diverse levels of transcriptional regulation, such as epigenetic intervention, inhibition of DNA-binding of transcriptional factors, and inhibition of the protein-protein interactions (PPIs), have been established in preclinically or clinically studies. In addition, several new approaches have recently been described, such as targeting proteasomal degradation and eliciting synthetic lethality. This review will emphasize on accentuating these developing therapeutic approaches and provide a thorough conspectus of the drug development to target key proteins involved in transcriptional regulation and their impact on future oncotherapy." @default.
- W4220808568 created "2022-04-03" @default.
- W4220808568 creator A5019188828 @default.
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- W4220808568 creator A5059777043 @default.
- W4220808568 creator A5065709521 @default.
- W4220808568 creator A5085665399 @default.
- W4220808568 date "2022-03-21" @default.
- W4220808568 modified "2023-10-01" @default.
- W4220808568 title "Targeting key proteins involved in transcriptional regulation for cancer therapy: Current strategies and future prospective" @default.
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