Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220808829> ?p ?o ?g. }
- W4220808829 endingPage "4129" @default.
- W4220808829 startingPage "4114" @default.
- W4220808829 abstract "Aging can lead to the occurrence of many degenerative diseases, and the most intuitive consequences are mainly manifested on the skin, which is affected by both endogenous and exogenous aging factors and can be used as an ideal model organ for studying aging. 4,4'-Dimethoxychalcone (DMC), a natural flavonoid compound from Angelica sinensis, has been proven to prolong the lifespan of multiple species. However, it is not clear whether it has the effect of delaying skin aging. This study aimed to establish a skin senescent cell model induced by oxidative stress, and further, to analyze the inhibitory effect of DMC on cellular senescence, and explore its molecular mechanisms. We found that treatment of HaCaT cells with 1 mM 2,2'-azobis(2-methylpropionamidine) dihydrochloride (AAPH) for 48 h showed significant senescent characteristics, which could be effectively alleviated by pretreatment with the antioxidant N-acetyl-L-cysteine (NAC). DMC significantly inhibited AAPH-induced senescence, and further mechanism studies showed that the activation of autophagy which depended on the phosphorylation of ULK1 at Ser555 was necessary for DMC to alleviate senescence of HaCaT cells. In addition, the mitogen-activated protein kinase (MAPK) signal pathway was also involved in the regulation of autophagy induced by DMC. These results were also validated in UVB-induced photoaging mice. In conclusion, we successfully establish a skin senescent cell model and prove that DMC can be used as a potential therapeutic agent to intervene in skin aging." @default.
- W4220808829 created "2022-04-03" @default.
- W4220808829 creator A5018817570 @default.
- W4220808829 creator A5027142223 @default.
- W4220808829 creator A5034187972 @default.
- W4220808829 creator A5042971509 @default.
- W4220808829 creator A5061884790 @default.
- W4220808829 creator A5062924912 @default.
- W4220808829 creator A5084094268 @default.
- W4220808829 date "2022-01-01" @default.
- W4220808829 modified "2023-09-30" @default.
- W4220808829 title "4,4′-Dimethoxychalcone protects the skin from AAPH-induced senescence and UVB-induced photoaging by activating autophagy" @default.
- W4220808829 cites W1565351177 @default.
- W4220808829 cites W1885920885 @default.
- W4220808829 cites W1914181484 @default.
- W4220808829 cites W1971285173 @default.
- W4220808829 cites W1997317531 @default.
- W4220808829 cites W2003170409 @default.
- W4220808829 cites W2010417927 @default.
- W4220808829 cites W2018396727 @default.
- W4220808829 cites W2044875500 @default.
- W4220808829 cites W2047330128 @default.
- W4220808829 cites W2071419221 @default.
- W4220808829 cites W2074957956 @default.
- W4220808829 cites W2126525177 @default.
- W4220808829 cites W2149771125 @default.
- W4220808829 cites W2155881038 @default.
- W4220808829 cites W2297495993 @default.
- W4220808829 cites W2305437520 @default.
- W4220808829 cites W2345614571 @default.
- W4220808829 cites W2529681420 @default.
- W4220808829 cites W2549552700 @default.
- W4220808829 cites W2559282809 @default.
- W4220808829 cites W2562237036 @default.
- W4220808829 cites W2592615787 @default.
- W4220808829 cites W2607214955 @default.
- W4220808829 cites W2624997514 @default.
- W4220808829 cites W2767885122 @default.
- W4220808829 cites W2773731557 @default.
- W4220808829 cites W2773814520 @default.
- W4220808829 cites W2799473901 @default.
- W4220808829 cites W2804257223 @default.
- W4220808829 cites W2890865075 @default.
- W4220808829 cites W2897996498 @default.
- W4220808829 cites W2903292083 @default.
- W4220808829 cites W2909477364 @default.
- W4220808829 cites W2915823245 @default.
- W4220808829 cites W2921170434 @default.
- W4220808829 cites W2943785490 @default.
- W4220808829 cites W2945298403 @default.
- W4220808829 cites W2947610223 @default.
- W4220808829 cites W2948225712 @default.
- W4220808829 cites W2959728234 @default.
- W4220808829 cites W2966014114 @default.
- W4220808829 cites W2985589213 @default.
- W4220808829 cites W2990285273 @default.
- W4220808829 cites W3007792051 @default.
- W4220808829 cites W3022066296 @default.
- W4220808829 cites W3056264410 @default.
- W4220808829 cites W3134729402 @default.
- W4220808829 cites W4210799840 @default.
- W4220808829 doi "https://doi.org/10.1039/d1fo04130d" @default.
- W4220808829 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35316314" @default.
- W4220808829 hasPublicationYear "2022" @default.
- W4220808829 type Work @default.
- W4220808829 citedByCount "3" @default.
- W4220808829 countsByYear W42208088292022 @default.
- W4220808829 countsByYear W42208088292023 @default.
- W4220808829 crossrefType "journal-article" @default.
- W4220808829 hasAuthorship W4220808829A5018817570 @default.
- W4220808829 hasAuthorship W4220808829A5027142223 @default.
- W4220808829 hasAuthorship W4220808829A5034187972 @default.
- W4220808829 hasAuthorship W4220808829A5042971509 @default.
- W4220808829 hasAuthorship W4220808829A5061884790 @default.
- W4220808829 hasAuthorship W4220808829A5062924912 @default.
- W4220808829 hasAuthorship W4220808829A5084094268 @default.
- W4220808829 hasConcept C118995209 @default.
- W4220808829 hasConcept C16005928 @default.
- W4220808829 hasConcept C16613235 @default.
- W4220808829 hasConcept C184235292 @default.
- W4220808829 hasConcept C185592680 @default.
- W4220808829 hasConcept C190283241 @default.
- W4220808829 hasConcept C202751555 @default.
- W4220808829 hasConcept C203522944 @default.
- W4220808829 hasConcept C2776151105 @default.
- W4220808829 hasConcept C2776960578 @default.
- W4220808829 hasConcept C2778004101 @default.
- W4220808829 hasConcept C2909910311 @default.
- W4220808829 hasConcept C522857546 @default.
- W4220808829 hasConcept C54355233 @default.
- W4220808829 hasConcept C55493867 @default.
- W4220808829 hasConcept C57074206 @default.
- W4220808829 hasConcept C71924100 @default.
- W4220808829 hasConcept C86803240 @default.
- W4220808829 hasConcept C95444343 @default.
- W4220808829 hasConcept C97029542 @default.
- W4220808829 hasConcept C98274493 @default.
- W4220808829 hasConceptScore W4220808829C118995209 @default.