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- W4220809213 endingPage "269" @default.
- W4220809213 startingPage "258" @default.
- W4220809213 abstract "Parkinson's disease (PD) is characterized by dopaminergic (DA) neuron loss and the formation of cytoplasmic protein inclusions. Although the exact pathogenesis of PD is unknown, iron dyshomeostasis has been proposed as a potential contributing factor. Emerging evidence suggests that glial cell activation plays a pivotal role in ferroptosis and subsequent neurodegeneration. We review the association between iron deposition, glial activation, and neuronal death, and discuss whether and how ferroptosis affects α-synuclein aggregation and DA neuron loss. We examine the possible roles of different types of glia in mediating ferroptosis in neurons. Lastly, we review current PD clinical trials targeting iron homeostasis. Although clinical trials are already evaluating ferroptosis modulation in PD, much remains unknown about metal ion metabolism and regulation in PD pathogenesis." @default.
- W4220809213 created "2022-04-03" @default.
- W4220809213 creator A5001969147 @default.
- W4220809213 creator A5017506393 @default.
- W4220809213 creator A5047844812 @default.
- W4220809213 creator A5086010931 @default.
- W4220809213 date "2022-04-01" @default.
- W4220809213 modified "2023-10-14" @default.
- W4220809213 title "Ferroptosis in Parkinson’s disease: glia–neuron crosstalk" @default.
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