Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220809307> ?p ?o ?g. }
- W4220809307 endingPage "525" @default.
- W4220809307 startingPage "513" @default.
- W4220809307 abstract "The goal of this study was to evaluate whether intermittent VNS reduces electrical heterogeneities and arrhythmia inducibility during sympathoexcitation.Sympathoexcitation increases the risk of ventricular tachyarrhythmias (VT). Vagal nerve stimulation (VNS) has been antiarrhythmic in the setting of ischemia-driven arrhythmias, but it is unclear if it can overcome the electrophysiological effects of sympathoexcitation in the setting of chronic myocardial infarction (MI).In Yorkshire pigs after chronic MI, a sternotomy was performed, a 56-electrode sock was placed over the ventricles (n = 17), and a basket catheter was positioned in the left ventricle (n = 6). Continuous unipolar electrograms from sock and basket arrays were obtained to analyze activation recovery interval (ARI), a surrogate of action potential duration. Bipolar voltage mapping was performed to define scar, border zone, or viable myocardium. Hemodynamic and electrical parameters and VT inducibility were evaluated during sympathoexcitation with bilateral stellate ganglia stimulation (BSS) and during combined BSS with intermittent VNS.During BSS, global epicardial ARIs shortened from 384 ± 59 milliseconds to 297 ± 63 milliseconds and endocardial ARIs from 359 ± 36 milliseconds to 318 ± 40 milliseconds. Dispersion in ARIs increased in all regions, with the greatest increase observed in scar and border zone regions. VNS mitigated the effects of BSS on border zone ARIs (from -18.3% ± 6.3% to -2.1% ± 14.7%) and ARI dispersion (from 104 ms2 [1 to 1,108 ms2] to -108 ms2 [IQR: -588 to 30 ms2]). VNS reduced VT inducibility during sympathoexcitation (from 75%-40%; P < 0.05).After chronic MI, VNS overcomes the detrimental effects of sympathoexcitation by reducing electrophysiological heterogeneities exacerbated by sympathetic stimulation, decreasing VT inducibility." @default.
- W4220809307 created "2022-04-03" @default.
- W4220809307 creator A5008254122 @default.
- W4220809307 creator A5010119614 @default.
- W4220809307 creator A5048074423 @default.
- W4220809307 creator A5051826640 @default.
- W4220809307 creator A5068836382 @default.
- W4220809307 creator A5074177770 @default.
- W4220809307 creator A5084726436 @default.
- W4220809307 creator A5085111298 @default.
- W4220809307 date "2022-04-01" @default.
- W4220809307 modified "2023-09-27" @default.
- W4220809307 title "Proarrhythmic Effects of Sympathetic Activation Are Mitigated by Vagal Nerve Stimulation in Infarcted Hearts" @default.
- W4220809307 cites W1968059705 @default.
- W4220809307 cites W1980338308 @default.
- W4220809307 cites W1983374780 @default.
- W4220809307 cites W1985854880 @default.
- W4220809307 cites W2007554162 @default.
- W4220809307 cites W2030429777 @default.
- W4220809307 cites W2038165405 @default.
- W4220809307 cites W2040537866 @default.
- W4220809307 cites W2041170885 @default.
- W4220809307 cites W2049604365 @default.
- W4220809307 cites W2052088259 @default.
- W4220809307 cites W2076935874 @default.
- W4220809307 cites W2095405649 @default.
- W4220809307 cites W2101234419 @default.
- W4220809307 cites W2101518281 @default.
- W4220809307 cites W2101719573 @default.
- W4220809307 cites W2116095873 @default.
- W4220809307 cites W2117330791 @default.
- W4220809307 cites W2118333950 @default.
- W4220809307 cites W2127160628 @default.
- W4220809307 cites W2128079378 @default.
- W4220809307 cites W2133127623 @default.
- W4220809307 cites W2138984876 @default.
- W4220809307 cites W2139412187 @default.
- W4220809307 cites W2145168941 @default.
- W4220809307 cites W2148936486 @default.
- W4220809307 cites W2162242381 @default.
- W4220809307 cites W2168926746 @default.
- W4220809307 cites W2213273623 @default.
- W4220809307 cites W2281452013 @default.
- W4220809307 cites W2329732856 @default.
- W4220809307 cites W2411031937 @default.
- W4220809307 cites W2562324550 @default.
- W4220809307 cites W2746154203 @default.
- W4220809307 cites W2752489571 @default.
- W4220809307 cites W2905514611 @default.
- W4220809307 cites W3002075194 @default.
- W4220809307 cites W3032081591 @default.
- W4220809307 cites W4206812823 @default.
- W4220809307 doi "https://doi.org/10.1016/j.jacep.2022.01.018" @default.
- W4220809307 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35450607" @default.
- W4220809307 hasPublicationYear "2022" @default.
- W4220809307 type Work @default.
- W4220809307 citedByCount "2" @default.
- W4220809307 countsByYear W42208093072022 @default.
- W4220809307 countsByYear W42208093072023 @default.
- W4220809307 crossrefType "journal-article" @default.
- W4220809307 hasAuthorship W4220809307A5008254122 @default.
- W4220809307 hasAuthorship W4220809307A5010119614 @default.
- W4220809307 hasAuthorship W4220809307A5048074423 @default.
- W4220809307 hasAuthorship W4220809307A5051826640 @default.
- W4220809307 hasAuthorship W4220809307A5068836382 @default.
- W4220809307 hasAuthorship W4220809307A5074177770 @default.
- W4220809307 hasAuthorship W4220809307A5084726436 @default.
- W4220809307 hasAuthorship W4220809307A5085111298 @default.
- W4220809307 hasBestOaLocation W42208093071 @default.
- W4220809307 hasConcept C126322002 @default.
- W4220809307 hasConcept C164705383 @default.
- W4220809307 hasConcept C185263204 @default.
- W4220809307 hasConcept C24998067 @default.
- W4220809307 hasConcept C2778921608 @default.
- W4220809307 hasConcept C2780087125 @default.
- W4220809307 hasConcept C2781404750 @default.
- W4220809307 hasConcept C42219234 @default.
- W4220809307 hasConcept C500558357 @default.
- W4220809307 hasConcept C71924100 @default.
- W4220809307 hasConceptScore W4220809307C126322002 @default.
- W4220809307 hasConceptScore W4220809307C164705383 @default.
- W4220809307 hasConceptScore W4220809307C185263204 @default.
- W4220809307 hasConceptScore W4220809307C24998067 @default.
- W4220809307 hasConceptScore W4220809307C2778921608 @default.
- W4220809307 hasConceptScore W4220809307C2780087125 @default.
- W4220809307 hasConceptScore W4220809307C2781404750 @default.
- W4220809307 hasConceptScore W4220809307C42219234 @default.
- W4220809307 hasConceptScore W4220809307C500558357 @default.
- W4220809307 hasConceptScore W4220809307C71924100 @default.
- W4220809307 hasIssue "4" @default.
- W4220809307 hasLocation W42208093071 @default.
- W4220809307 hasLocation W42208093072 @default.
- W4220809307 hasOpenAccess W4220809307 @default.
- W4220809307 hasPrimaryLocation W42208093071 @default.
- W4220809307 hasRelatedWork W2045390961 @default.
- W4220809307 hasRelatedWork W2049397185 @default.
- W4220809307 hasRelatedWork W2093502227 @default.
- W4220809307 hasRelatedWork W2159512267 @default.