FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220809612> ?p ?o ?g. }

• W4220809612 abstract "Abstract Objectives Intermittent fasting boosts some mechanisms of host defense against infection while modulating the inflammatory response. Lower-frequency periodic fasting is associated with greater survival and lower risk of comorbidities that exacerbate COVID-19. This study evaluated the association of periodic fasting with COVID-19 severity and, secondarily, initial diagnosis of infection by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Design Prospective longitudinal observational cohort study. Setting Single-center secondary care facility in Salt Lake City, Utah, USA with follow-up across a 24-hospital integrated healthcare system. Participants Patients enrolled in the INSPIRE registry in 2013-2020 were studied if they had SARS-CoV-2 testing in March 2020-February 2021 and either tested positive (N=205) for the primary outcome evaluation or had a positive or negative test result for evaluation of the secondary outcome (n=1,524). Interventions No treatment assignments were made; individuals provided information about their personal practice and history of engaging in routine periodic fasting across their lifespan. Main outcome measures The association of periodic fasting with a composite of mortality or hospitalization as the primary outcome was evaluated by Cox regression through February 2021 and multivariable adjustments considered 36 covariables in INSPIRE patients diagnosed with COVID-19. Secondary analysis evaluated the association of fasting with testing positive for SARS-CoV-2 in INSPIRE patients evaluated for COVID-19 (n=1,524). Results Subjects engaging in periodic fasting (n=73, 35.6%) did so for 40.4±20.6 years (max: 81.9 years) prior to COVID-19 diagnosis. The composite outcome occurred in 11.0% of periodic fasters and 28.8% of non-fasters (p=0.013), with HR=0.61 (95% CI=0.42, 0.90) favoring fasting. Multivariable analyses confirmed this association. Other predictors of hospitalization/mortality were age, Hispanic ethnicity, prior MI, prior TIA, and renal failure, with trends for race, smoking, hyperlipidemia, coronary disease, diabetes, heart failure, and history of anxiety, but not alcohol use. In secondary analysis, COVID-19 was diagnosed in 14.3% of fasters and 13.0% of non-fasters (p=0.51). Conclusions Routine periodic fasting was associated with a lower risk of hospitalization or mortality in patients with COVID-19. Fasting may be a complementary therapy to vaccination that could provide immune support and hyperinflammation control during and beyond the pandemic. Trial registration clinicaltrials.gov , NCT02450006 (the INSPIRE registry) Summary What is already known on this topic During a period of energy restriction, fasting controls inflammation by dampening the cytokine cascade and it switches the metabolic source of energy from glucose to fats, including by increasing circulating free fatty acids such as linoleic acid. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) receptor binding domains bind linoleic acid in pockets that, when bound, reduce spike protein affinity for the angiotensin-converting enzyme 2. Repeated fasting boosts basal levels of some parameters related to inflammation control and host defense against infections, including galectin-3, and it ameliorates insulin resistance and cardiovascular risks such that periodic fasting is associated with greater survival and lower risk of heart failure, coronary artery disease, and type 2 diabetes. What this study adds This study evaluated the association of periodic fasting with severity of coronavirus disease 2019 (COVID-19) and with initial infection with SARS-CoV-2 in a population where a substantial proportion of people routinely engage in periodic dry or water-only fasting, primarily for religious purposes. This observational epidemiologic study found that routine low-frequency periodic fasting for an average of >40 years was associated with a lower risk of a composite of hospitalization or mortality after COVID-19 diagnosis, suggesting that fasting deserves further investigation as a complementary approach along with vaccines for reducing COVID-19 severity. The study also found no association of periodic fasting with the onset of SARS-CoV-2 infection. Trial registration The Intermountain INSPIRE registry ( clinicaltrials.gov , NCT02450006 ) Transparency BDH affirms that the manuscript is an honest, accurate, and transparent account of the study being reported and that no important aspects of the study have been omitted. Copyright The Corresponding Author has the right to grant on behalf of all authors and does grant on behalf of all authors, a worldwide licence to the Publishers and its licensees in perpetuity, in all forms, formats and media (whether known now or created in the future), to i) publish, reproduce, distribute, display and store the Contribution, ii) translate the Contribution into other languages, create adaptations, reprints, include within collections and create summaries, extracts and/or, abstracts of the Contribution, iii) create any other derivative work(s) based on the Contribution, iv) to exploit all subsidiary rights in the Contribution, v) the inclusion of electronic links from the Contribution to third party material where-ever it may be located; and, vi) licence any third party to do any or all of the above." @default.
• W4220809612 created "2022-04-03" @default.
• W4220809612 creator A5051547394 @default.
• W4220809612 creator A5065391918 @default.
• W4220809612 creator A5067666881 @default.
• W4220809612 creator A5071011669 @default.
• W4220809612 creator A5077701573 @default.
• W4220809612 creator A5087983572 @default.
• W4220809612 creator A5089940190 @default.
• W4220809612 date "2022-03-20" @default.
• W4220809612 modified "2023-10-18" @default.
• W4220809612 title "Association of Periodic Fasting with Lower Severity of COVID-19 Outcomes in the SARS-CoV-2 Pre-Vaccine Era: An Observational Cohort from the INSPIRE Registry" @default.
• W4220809612 cites W147957900 @default.
• W4220809612 cites W1971386376 @default.
• W4220809612 cites W1974711337 @default.
• W4220809612 cites W2043427885 @default.
• W4220809612 cites W2048178709 @default.
• W4220809612 cites W2051879843 @default.
• W4220809612 cites W2074389346 @default.
• W4220809612 cites W2079577855 @default.
• W4220809612 cites W2097960045 @default.
• W4220809612 cites W2101965458 @default.
• W4220809612 cites W2168048360 @default.
• W4220809612 cites W2625462710 @default.
• W4220809612 cites W2799787925 @default.
• W4220809612 cites W2883468517 @default.
• W4220809612 cites W2914836926 @default.
• W4220809612 cites W2915542343 @default.
• W4220809612 cites W2977313709 @default.
• W4220809612 cites W3008443627 @default.
• W4220809612 cites W3038760650 @default.
• W4220809612 cites W3041792912 @default.
• W4220809612 cites W3087409770 @default.
• W4220809612 cites W3088609942 @default.
• W4220809612 cites W3101243097 @default.
• W4220809612 cites W3103768255 @default.
• W4220809612 cites W3137361531 @default.
• W4220809612 cites W3157462878 @default.
• W4220809612 cites W3172953913 @default.
• W4220809612 cites W3175669568 @default.
• W4220809612 cites W3190088157 @default.
• W4220809612 cites W3196696572 @default.
• W4220809612 doi "https://doi.org/10.1101/2022.03.17.22272577" @default.
• W4220809612 hasPublicationYear "2022" @default.
• W4220809612 type Work @default.
• W4220809612 citedByCount "3" @default.
• W4220809612 countsByYear W42208096122022 @default.
• W4220809612 countsByYear W42208096122023 @default.
• W4220809612 crossrefType "posted-content" @default.
• W4220809612 hasAuthorship W4220809612A5051547394 @default.
• W4220809612 hasAuthorship W4220809612A5065391918 @default.
• W4220809612 hasAuthorship W4220809612A5067666881 @default.
• W4220809612 hasAuthorship W4220809612A5071011669 @default.
• W4220809612 hasAuthorship W4220809612A5077701573 @default.
• W4220809612 hasAuthorship W4220809612A5087983572 @default.
• W4220809612 hasAuthorship W4220809612A5089940190 @default.
• W4220809612 hasBestOaLocation W42208096121 @default.
• W4220809612 hasConcept C118552586 @default.
• W4220809612 hasConcept C126322002 @default.
• W4220809612 hasConcept C187212893 @default.
• W4220809612 hasConcept C188816634 @default.
• W4220809612 hasConcept C194828623 @default.
• W4220809612 hasConcept C201903717 @default.
• W4220809612 hasConcept C23131810 @default.
• W4220809612 hasConcept C27415008 @default.
• W4220809612 hasConcept C2779134260 @default.
• W4220809612 hasConcept C3007834351 @default.
• W4220809612 hasConcept C3008058167 @default.
• W4220809612 hasConcept C50382708 @default.
• W4220809612 hasConcept C524204448 @default.
• W4220809612 hasConcept C71924100 @default.
• W4220809612 hasConcept C72563966 @default.
• W4220809612 hasConceptScore W4220809612C118552586 @default.
• W4220809612 hasConceptScore W4220809612C126322002 @default.
• W4220809612 hasConceptScore W4220809612C187212893 @default.
• W4220809612 hasConceptScore W4220809612C188816634 @default.
• W4220809612 hasConceptScore W4220809612C194828623 @default.
• W4220809612 hasConceptScore W4220809612C201903717 @default.
• W4220809612 hasConceptScore W4220809612C23131810 @default.
• W4220809612 hasConceptScore W4220809612C27415008 @default.
• W4220809612 hasConceptScore W4220809612C2779134260 @default.
• W4220809612 hasConceptScore W4220809612C3007834351 @default.
• W4220809612 hasConceptScore W4220809612C3008058167 @default.
• W4220809612 hasConceptScore W4220809612C50382708 @default.
• W4220809612 hasConceptScore W4220809612C524204448 @default.
• W4220809612 hasConceptScore W4220809612C71924100 @default.
• W4220809612 hasConceptScore W4220809612C72563966 @default.
• W4220809612 hasLocation W42208096121 @default.
• W4220809612 hasOpenAccess W4220809612 @default.
• W4220809612 hasPrimaryLocation W42208096121 @default.
• W4220809612 hasRelatedWork W3081622774 @default.
• W4220809612 hasRelatedWork W3134064893 @default.
• W4220809612 hasRelatedWork W3161920997 @default.
• W4220809612 hasRelatedWork W3181290183 @default.
• W4220809612 hasRelatedWork W3197961698 @default.
• W4220809612 hasRelatedWork W3205082106 @default.
• W4220809612 hasRelatedWork W3217408445 @default.
• W4220809612 hasRelatedWork W4212833090 @default.
• W4220809612 hasRelatedWork W4283162725 @default.
• W4220809612 hasRelatedWork W4287297964 @default.

• next