FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220809750> ?p ?o ?g. }

• W4220809750 abstract "The decrease of bone mineral density (BMD) after the intake of Tenofovir disoproxil fumarate (TDF)-based drugs in people living with HIV/AIDS (PLWHA) and HIV-negative key populations under pre-exposure prophylaxis (PrEP) regimen raised concerns. Previous findings on the effects of vitamin D (VD) and calcium supplements and the recovery of BMD loss were inconclusive. The optimal doses of VD and calcium and its supplementary duration remained unknown. Therefore, we conducted a systematic review and meta-analysis to synthesize current evidence on VD and calcium supplements to inform clinical practice.We searched PubMed, Web of Science, Cochrane library, and EMBASE databases for all placebo-controlled trials and prospective cohort studies published before March 5, 2021 that investigated VD and calcium supplements in participants taking TDF-based drugs. The keywords calcium, vitamin D, Tenofovir, and BMD were used for the searches. The primary outcome was changes of spine and hip BMD. A subgroup analysis was performed to determine the factors that were related to the effects of VD supplements on BMD. Locally weighted regression (loess) was used to determine the relationships of VD supplements, supplementary duration, and changes of BMD. This study was registered at PROSPERO (No. 42021231000).Seven eligible studies including 703 participants were included in the analyses. The meta-analysis found that VD and calcium supplementation was related to a significant increase of BMD in the spine and hip [standardized mean difference (SMD) 0.43; 95% CI, 0.25 to 0.61, p = 0.009]. Moreover, positive dose-response relationships were demonstrated between doses of VD and calcium supplements, supplementary duration, and BMD recovery. Patients who took VD with the dose level of 4,000 IU/D obtained the highest BMD improvement (SMD 0.59, 95% CI, 0.43 to 0.74). No side effects were reported on VD and calcium supplementation.We found the VD and calcium supplementation was associated with increases of BMD in participants taking TDF-based drugs. An optimal supplementary dose of 4,000 IU/D for VD was suggested for clinicians. The findings could be used in clinical practice to improve the BMD outcomes in people who were taking TDF-based drugs.Systematic Review Registration: https://www.crd.york.ac.uk/PROSPERO/." @default.
• W4220809750 created "2022-04-03" @default.
• W4220809750 creator A5001999511 @default.
• W4220809750 creator A5002003385 @default.
• W4220809750 creator A5015277544 @default.
• W4220809750 creator A5033073898 @default.
• W4220809750 creator A5039905531 @default.
• W4220809750 creator A5049494334 @default.
• W4220809750 creator A5077095023 @default.
• W4220809750 creator A5086615075 @default.
• W4220809750 creator A5090036443 @default.
• W4220809750 creator A5090911302 @default.
• W4220809750 date "2022-03-31" @default.
• W4220809750 modified "2023-09-26" @default.
• W4220809750 title "Vitamin D and Calcium Supplementation Reverses Tenofovir-Caused Bone Mineral Density Loss in People Taking ART or PrEP: A Systematic Review and Meta-Analysis" @default.
• W4220809750 cites W1552487149 @default.
• W4220809750 cites W1972526543 @default.
• W4220809750 cites W2032448658 @default.
• W4220809750 cites W2046828062 @default.
• W4220809750 cites W2056779298 @default.
• W4220809750 cites W2096150279 @default.
• W4220809750 cites W2144095981 @default.
• W4220809750 cites W2144658061 @default.
• W4220809750 cites W2546752129 @default.
• W4220809750 cites W2730313341 @default.
• W4220809750 cites W2753816045 @default.
• W4220809750 cites W2774276060 @default.
• W4220809750 cites W2791032589 @default.
• W4220809750 cites W2901087754 @default.
• W4220809750 cites W2907665779 @default.
• W4220809750 cites W2947274344 @default.
• W4220809750 cites W2947813238 @default.
• W4220809750 cites W2950611656 @default.
• W4220809750 cites W2966680488 @default.
• W4220809750 cites W2970181397 @default.
• W4220809750 cites W2975914964 @default.
• W4220809750 cites W2999156031 @default.
• W4220809750 cites W3003135182 @default.
• W4220809750 cites W3013998131 @default.
• W4220809750 cites W3034885331 @default.
• W4220809750 cites W3049006573 @default.
• W4220809750 cites W3087745518 @default.
• W4220809750 cites W3091955100 @default.
• W4220809750 cites W3092339660 @default.
• W4220809750 cites W3107822668 @default.
• W4220809750 cites W3112841494 @default.
• W4220809750 cites W3127127167 @default.
• W4220809750 cites W3164635421 @default.
• W4220809750 cites W4230174434 @default.
• W4220809750 cites W4288097655 @default.
• W4220809750 doi "https://doi.org/10.3389/fnut.2022.749948" @default.
• W4220809750 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35433788" @default.
• W4220809750 hasPublicationYear "2022" @default.
• W4220809750 type Work @default.
• W4220809750 citedByCount "1" @default.
• W4220809750 countsByYear W42208097502023 @default.
• W4220809750 crossrefType "journal-article" @default.
• W4220809750 hasAuthorship W4220809750A5001999511 @default.
• W4220809750 hasAuthorship W4220809750A5002003385 @default.
• W4220809750 hasAuthorship W4220809750A5015277544 @default.
• W4220809750 hasAuthorship W4220809750A5033073898 @default.
• W4220809750 hasAuthorship W4220809750A5039905531 @default.
• W4220809750 hasAuthorship W4220809750A5049494334 @default.
• W4220809750 hasAuthorship W4220809750A5077095023 @default.
• W4220809750 hasAuthorship W4220809750A5086615075 @default.
• W4220809750 hasAuthorship W4220809750A5090036443 @default.
• W4220809750 hasAuthorship W4220809750A5090911302 @default.
• W4220809750 hasBestOaLocation W42208097501 @default.
• W4220809750 hasConcept C124490489 @default.
• W4220809750 hasConcept C126322002 @default.
• W4220809750 hasConcept C142724271 @default.
• W4220809750 hasConcept C187960798 @default.
• W4220809750 hasConcept C204787440 @default.
• W4220809750 hasConcept C27081682 @default.
• W4220809750 hasConcept C2776478404 @default.
• W4220809750 hasConcept C2776541429 @default.
• W4220809750 hasConcept C2776886416 @default.
• W4220809750 hasConcept C2777724520 @default.
• W4220809750 hasConcept C2781413609 @default.
• W4220809750 hasConcept C519063684 @default.
• W4220809750 hasConcept C71924100 @default.
• W4220809750 hasConcept C95190672 @default.
• W4220809750 hasConceptScore W4220809750C124490489 @default.
• W4220809750 hasConceptScore W4220809750C126322002 @default.
• W4220809750 hasConceptScore W4220809750C142724271 @default.
• W4220809750 hasConceptScore W4220809750C187960798 @default.
• W4220809750 hasConceptScore W4220809750C204787440 @default.
• W4220809750 hasConceptScore W4220809750C27081682 @default.
• W4220809750 hasConceptScore W4220809750C2776478404 @default.
• W4220809750 hasConceptScore W4220809750C2776541429 @default.
• W4220809750 hasConceptScore W4220809750C2776886416 @default.
• W4220809750 hasConceptScore W4220809750C2777724520 @default.
• W4220809750 hasConceptScore W4220809750C2781413609 @default.
• W4220809750 hasConceptScore W4220809750C519063684 @default.
• W4220809750 hasConceptScore W4220809750C71924100 @default.
• W4220809750 hasConceptScore W4220809750C95190672 @default.
• W4220809750 hasLocation W42208097501 @default.
• W4220809750 hasLocation W42208097502 @default.
• W4220809750 hasLocation W42208097503 @default.
• W4220809750 hasOpenAccess W4220809750 @default.

• next