Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220809871> ?p ?o ?g. }
- W4220809871 abstract "Abstract The COVID-19 pandemic began in 2019, but it is still active. The development of an effective vaccine reduced the number of deaths; however, a treatment is still needed. Here, we aimed to inhibit viral entry to the host cell by inhibiting Spike (S) protein cleavage by several proteases. We develop a computational pipeline to repurpose FDA-approved drugs to inhibit protease activity and thus prevent S protein cleavage. We tested some of our drug candidates and demonstrated a decrease in protease activity. We believe our pipeline will be beneficial in identifying a drug regimen for COVID-19 patients." @default.
- W4220809871 created "2022-04-03" @default.
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- W4220809871 date "2022-03-07" @default.
- W4220809871 modified "2023-09-27" @default.
- W4220809871 title "<i>In silico</i> screening and testing of FDA approved small molecules to block SARS-CoV-2 entry to the host cell by inhibiting Spike protein cleavage" @default.
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- W4220809871 doi "https://doi.org/10.1101/2022.03.07.483324" @default.
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