FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220809997> ?p ?o ?g. }

• W4220809997 abstract "During loading of viscoelastic tissues, part of the mechanical energy is transformed into heat that can locally increase the tissue temperature, a phenomenon known as self-heating. In the framework of mechanobiology, it has been accepted that cells react and adapt to mechanical stimuli. However, the cellular effect of temperature increase as a by-product of loading has been widely neglected. In this work, we focused on cartilage self-heating to present a 'thermo-mechanobiological' paradigm, and demonstrate how the coupling of a biomimetic temperature evolution and mechanical loading could influence cell behavior. We thereby developed a customized in vitro system allowing to recapitulate pertinent in vivo physical cues and determined the cells chondrogenic response to thermal and/or mechanical stimuli. Cellular mechanisms of action and potential signaling pathways of thermo-mechanotransduction process were also investigated. We found that co-existence of thermo-mechanical cues had a superior effect on chondrogenic gene expression compared to either signal alone. Specifically, the expression of Sox9 was significantly upregulated by application of the physiological thermo-mechanical stimulus. Multimodal transient receptor potential vanilloid 4 (TRPV4) channels were identified as key mediators of thermo-mechanotransduction process, which becomes ineffective without external calcium sources. We also observed that the isolated temperature evolution, as a by-product of loading, is a contributing factor to the cell response and this could be considered as important as the conventional mechanical loading. Providing an optimal thermo-mechanical environment by synergy of heat and loading portrays new opportunity for development of novel treatments for cartilage regeneration and can furthermore signal key elements for emerging cell-based therapies." @default.
• W4220809997 created "2022-04-03" @default.
• W4220809997 creator A5004548179 @default.
• W4220809997 creator A5032764121 @default.
• W4220809997 creator A5032987278 @default.
• W4220809997 creator A5057760870 @default.
• W4220809997 creator A5059340413 @default.
• W4220809997 creator A5067415588 @default.
• W4220809997 creator A5087847756 @default.
• W4220809997 creator A5091109609 @default.
• W4220809997 date "2022-03-08" @default.
• W4220809997 modified "2023-09-26" @default.
• W4220809997 title "Temperature evolution following joint loading promotes chondrogenesis by synergistic cues via calcium signaling" @default.
• W4220809997 cites W1520842759 @default.
• W4220809997 cites W1812743645 @default.
• W4220809997 cites W1974352390 @default.
• W4220809997 cites W1995829436 @default.
• W4220809997 cites W2000465700 @default.
• W4220809997 cites W2003684547 @default.
• W4220809997 cites W2010240830 @default.
• W4220809997 cites W2017435196 @default.
• W4220809997 cites W2036145275 @default.
• W4220809997 cites W2041099873 @default.
• W4220809997 cites W2041452359 @default.
• W4220809997 cites W2046507356 @default.
• W4220809997 cites W2049247347 @default.
• W4220809997 cites W2053413775 @default.
• W4220809997 cites W2055588361 @default.
• W4220809997 cites W2056361979 @default.
• W4220809997 cites W2058152417 @default.
• W4220809997 cites W2060667756 @default.
• W4220809997 cites W2064962545 @default.
• W4220809997 cites W2069871934 @default.
• W4220809997 cites W2076605676 @default.
• W4220809997 cites W2077741258 @default.
• W4220809997 cites W2080234284 @default.
• W4220809997 cites W2087850490 @default.
• W4220809997 cites W2091217432 @default.
• W4220809997 cites W2093970951 @default.
• W4220809997 cites W2100132015 @default.
• W4220809997 cites W2107277218 @default.
• W4220809997 cites W2109995938 @default.
• W4220809997 cites W2118622904 @default.
• W4220809997 cites W2126464829 @default.
• W4220809997 cites W2126997734 @default.
• W4220809997 cites W2139205623 @default.
• W4220809997 cites W2141865080 @default.
• W4220809997 cites W2150134228 @default.
• W4220809997 cites W2150722239 @default.
• W4220809997 cites W2159542600 @default.
• W4220809997 cites W2163469138 @default.
• W4220809997 cites W2192080449 @default.
• W4220809997 cites W2275769872 @default.
• W4220809997 cites W2319797071 @default.
• W4220809997 cites W2410997457 @default.
• W4220809997 cites W2469640112 @default.
• W4220809997 cites W2473018992 @default.
• W4220809997 cites W2476542314 @default.
• W4220809997 cites W2522646642 @default.
• W4220809997 cites W2582009831 @default.
• W4220809997 cites W2602902934 @default.
• W4220809997 cites W2737023933 @default.
• W4220809997 cites W2762913705 @default.
• W4220809997 cites W2763052316 @default.
• W4220809997 cites W2775074618 @default.
• W4220809997 cites W2789854659 @default.
• W4220809997 cites W2801630192 @default.
• W4220809997 cites W2802071226 @default.
• W4220809997 cites W2907538099 @default.
• W4220809997 cites W2908883259 @default.
• W4220809997 cites W2914795187 @default.
• W4220809997 cites W2979122528 @default.
• W4220809997 cites W3093813118 @default.
• W4220809997 cites W3126903269 @default.
• W4220809997 cites W3134609098 @default.
• W4220809997 cites W3142090326 @default.
• W4220809997 doi "https://doi.org/10.7554/elife.72068" @default.
• W4220809997 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35256051" @default.
• W4220809997 hasPublicationYear "2022" @default.
• W4220809997 type Work @default.
• W4220809997 citedByCount "7" @default.
• W4220809997 countsByYear W42208099972022 @default.
• W4220809997 countsByYear W42208099972023 @default.
• W4220809997 crossrefType "journal-article" @default.
• W4220809997 hasAuthorship W4220809997A5004548179 @default.
• W4220809997 hasAuthorship W4220809997A5032764121 @default.
• W4220809997 hasAuthorship W4220809997A5032987278 @default.
• W4220809997 hasAuthorship W4220809997A5057760870 @default.
• W4220809997 hasAuthorship W4220809997A5059340413 @default.
• W4220809997 hasAuthorship W4220809997A5067415588 @default.
• W4220809997 hasAuthorship W4220809997A5087847756 @default.
• W4220809997 hasAuthorship W4220809997A5091109609 @default.
• W4220809997 hasBestOaLocation W42208099971 @default.
• W4220809997 hasConcept C12554922 @default.
• W4220809997 hasConcept C155164980 @default.
• W4220809997 hasConcept C170493617 @default.
• W4220809997 hasConcept C181104049 @default.
• W4220809997 hasConcept C185592680 @default.
• W4220809997 hasConcept C192562407 @default.
• W4220809997 hasConcept C2780171871 @default.

• next