FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220811714> ?p ?o ?g. }

• W4220811714 endingPage "215.e6" @default.
• W4220811714 startingPage "204" @default.
• W4220811714 abstract "There is a critical need for rapid viral infection diagnostics to enable prompt case identification in pandemic settings and support targeted antimicrobial prescribing.Using untargeted high-resolution liquid chromatography coupled with mass spectrometry, we compared the admission serum metabolome of emergency department patients with viral infections (including COVID-19), bacterial infections, inflammatory conditions, and healthy controls. Sera from an independent cohort of emergency department patients admitted with viral or bacterial infections underwent profiling to validate findings. Associations between whole-blood gene expression and the identified metabolite of interest were examined.3'-Deoxy-3',4'-didehydro-cytidine (ddhC), a free base of the only known human antiviral small molecule ddhC-triphosphate (ddhCTP), was detected for the first time in serum. When comparing 60 viral with 101 non-viral cases in the discovery cohort, ddhC was the most significantly differentially abundant metabolite, generating an area under the receiver operating characteristic curve (AUC) of 0.954 (95% CI: 0.923-0.986). In the validation cohort, ddhC was again the most significantly differentially abundant metabolite when comparing 40 viral with 40 bacterial cases, generating an AUC of 0.81 (95% CI 0.708-0.915). Transcripts of viperin and CMPK2, enzymes responsible for ddhCTP synthesis, were among the five genes most highly correlated with ddhC abundance.The antiviral precursor molecule ddhC is detectable in serum and an accurate marker for acute viral infection. Interferon-inducible genes viperin and CMPK2 are implicated in ddhC production in vivo. These findings highlight a future diagnostic role for ddhC in viral diagnosis, pandemic preparedness, and acute infection management.NIHR Imperial BRC; UKRI." @default.
• W4220811714 created "2022-04-03" @default.
• W4220811714 creator A5003517788 @default.
• W4220811714 creator A5011680834 @default.
• W4220811714 creator A5015508529 @default.
• W4220811714 creator A5018876652 @default.
• W4220811714 creator A5026616389 @default.
• W4220811714 creator A5027465727 @default.
• W4220811714 creator A5032097673 @default.
• W4220811714 creator A5033418317 @default.
• W4220811714 creator A5035798742 @default.
• W4220811714 creator A5041443809 @default.
• W4220811714 creator A5048603885 @default.
• W4220811714 creator A5056505013 @default.
• W4220811714 creator A5061187207 @default.
• W4220811714 creator A5066895396 @default.
• W4220811714 creator A5068013870 @default.
• W4220811714 creator A5076028105 @default.
• W4220811714 creator A5077554827 @default.
• W4220811714 creator A5078419582 @default.
• W4220811714 date "2022-03-01" @default.
• W4220811714 modified "2023-10-16" @default.
• W4220811714 title "Antiviral metabolite 3′-deoxy-3′,4′-didehydro-cytidine is detectable in serum and identifies acute viral infections including COVID-19" @default.
• W4220811714 cites W1550213267 @default.
• W4220811714 cites W1964010911 @default.
• W4220811714 cites W2006617902 @default.
• W4220811714 cites W2081465448 @default.
• W4220811714 cites W2088992962 @default.
• W4220811714 cites W2102619694 @default.
• W4220811714 cites W2108234281 @default.
• W4220811714 cites W2138207763 @default.
• W4220811714 cites W2152575748 @default.
• W4220811714 cites W2169456326 @default.
• W4220811714 cites W2179438025 @default.
• W4220811714 cites W2339084922 @default.
• W4220811714 cites W2432815617 @default.
• W4220811714 cites W2500755047 @default.
• W4220811714 cites W2516755168 @default.
• W4220811714 cites W2767683865 @default.
• W4220811714 cites W2786394271 @default.
• W4220811714 cites W2809660639 @default.
• W4220811714 cites W2881018690 @default.
• W4220811714 cites W2885381384 @default.
• W4220811714 cites W2900483646 @default.
• W4220811714 cites W2907919699 @default.
• W4220811714 cites W2964721899 @default.
• W4220811714 cites W2990032304 @default.
• W4220811714 cites W3028711203 @default.
• W4220811714 cites W3042238480 @default.
• W4220811714 cites W3049668722 @default.
• W4220811714 cites W3087038497 @default.
• W4220811714 cites W3088521497 @default.
• W4220811714 cites W3091839106 @default.
• W4220811714 cites W3092863233 @default.
• W4220811714 cites W3119330152 @default.
• W4220811714 cites W3120038138 @default.
• W4220811714 cites W3134761573 @default.
• W4220811714 cites W3170571370 @default.
• W4220811714 cites W3172727636 @default.
• W4220811714 cites W3194622638 @default.
• W4220811714 cites W3202008685 @default.
• W4220811714 cites W4205247356 @default.
• W4220811714 doi "https://doi.org/10.1016/j.medj.2022.01.009" @default.
• W4220811714 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35128501" @default.
• W4220811714 hasPublicationYear "2022" @default.
• W4220811714 type Work @default.
• W4220811714 citedByCount "9" @default.
• W4220811714 countsByYear W42208117142022 @default.
• W4220811714 countsByYear W42208117142023 @default.
• W4220811714 crossrefType "journal-article" @default.
• W4220811714 hasAuthorship W4220811714A5003517788 @default.
• W4220811714 hasAuthorship W4220811714A5011680834 @default.
• W4220811714 hasAuthorship W4220811714A5015508529 @default.
• W4220811714 hasAuthorship W4220811714A5018876652 @default.
• W4220811714 hasAuthorship W4220811714A5026616389 @default.
• W4220811714 hasAuthorship W4220811714A5027465727 @default.
• W4220811714 hasAuthorship W4220811714A5032097673 @default.
• W4220811714 hasAuthorship W4220811714A5033418317 @default.
• W4220811714 hasAuthorship W4220811714A5035798742 @default.
• W4220811714 hasAuthorship W4220811714A5041443809 @default.
• W4220811714 hasAuthorship W4220811714A5048603885 @default.
• W4220811714 hasAuthorship W4220811714A5056505013 @default.
• W4220811714 hasAuthorship W4220811714A5061187207 @default.
• W4220811714 hasAuthorship W4220811714A5066895396 @default.
• W4220811714 hasAuthorship W4220811714A5068013870 @default.
• W4220811714 hasAuthorship W4220811714A5076028105 @default.
• W4220811714 hasAuthorship W4220811714A5077554827 @default.
• W4220811714 hasAuthorship W4220811714A5078419582 @default.
• W4220811714 hasBestOaLocation W42208117141 @default.
• W4220811714 hasConcept C126322002 @default.
• W4220811714 hasConcept C135870905 @default.
• W4220811714 hasConcept C142462285 @default.
• W4220811714 hasConcept C159047783 @default.
• W4220811714 hasConcept C203014093 @default.
• W4220811714 hasConcept C2522874641 @default.
• W4220811714 hasConcept C2776178377 @default.
• W4220811714 hasConcept C2777477808 @default.
• W4220811714 hasConcept C71924100 @default.

• next