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- W4220819005 abstract "Malignant mesothelioma (MM) is a malignancy that arises from the mesothelium, a thin layer of tissue that covers the body’s serous cavities, such as the pleural, peritoneal, pericardial, and tunica vaginalis of the testis. More than 80% of all mesothelioma cases originate from the pleura and approximately 75–80% of patients are males. It is almost always fatal with most of those affected dying within a year of diagnosis. Asbestos exposure is the most common cause of MM, which mostly affects the pleura. Various factors, including other mineral fibers, carbon nanotubes, or genetic mutations, are also suggested to have a role in the development of MM. The involvement of asbestos, other mineral fibers, nanotechnological products, the simian virus SV40, ionizing radiation, genetic factors, and inflammation in the development of MM has been discussed in this chapter. This study focuses on the role of other mineral fibers, such as erionite, fluoroedenite, balangeroite, and carbon nanotubes, as well as genetic mutations in BAP1 and other genes, in the pathogenesis of MM. The etiology of MM is considered to be complex, and greater knowledge of the pathogenetic pathways may lead to the identification of effective and personalized treatment targets." @default.
- W4220819005 created "2022-04-03" @default.
- W4220819005 creator A5029488087 @default.
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- W4220819005 creator A5064983758 @default.
- W4220819005 creator A5076825236 @default.
- W4220819005 creator A5083460546 @default.
- W4220819005 date "2022-12-21" @default.
- W4220819005 modified "2023-10-10" @default.
- W4220819005 title "Causes and Pathogenesis of Malignant Mesothelioma" @default.
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