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- W4220819374 endingPage "519" @default.
- W4220819374 startingPage "519" @default.
- W4220819374 abstract "Calprotectin, a heterodimer of S100A8 and S100A9 EF-hand calcium-binding proteins, is an integral part of the innate immune response. Calprotectin (CP) serves as a ligand for several pattern recognition cell surface receptors including the receptor for advanced glycation end products (RAGE), toll-like receptor 4 (TLR4), and cluster of differentiation 33 (CD33). The receptors initiate kinase signaling cascades that activate inflammation through the NF-kB pathway. Receptor activation by CP leads to upregulation of both receptor and ligand, a positive feedback loop associated with specific chronic inflammatory syndromes. Hence, CP and its two constituent homodimers have been viewed as potential targets to suppress certain chronic inflammation pathologies. A variety of inhibitors of CP and other S100 proteins have been investigated for more than 30 years, but no candidates have advanced significantly into clinical trials. Here, current knowledge of the interactions of CP with its receptors is reviewed along with recent progress towards the development of CP-directed chemotherapeutics." @default.
- W4220819374 created "2022-04-03" @default.
- W4220819374 creator A5025090033 @default.
- W4220819374 creator A5039089094 @default.
- W4220819374 creator A5071283460 @default.
- W4220819374 date "2022-03-30" @default.
- W4220819374 modified "2023-10-09" @default.
- W4220819374 title "A Structural Perspective on Calprotectin as a Ligand of Receptors Mediating Inflammation and Potential Drug Target" @default.
- W4220819374 cites W1143127356 @default.
- W4220819374 cites W1567450894 @default.
- W4220819374 cites W1598235393 @default.
- W4220819374 cites W162166184 @default.
- W4220819374 cites W1751974138 @default.
- W4220819374 cites W1853529910 @default.
- W4220819374 cites W1968594434 @default.
- W4220819374 cites W1969886451 @default.
- W4220819374 cites W1971907885 @default.
- W4220819374 cites W1972050454 @default.
- W4220819374 cites W1972816014 @default.
- W4220819374 cites W1978415870 @default.
- W4220819374 cites W1984830754 @default.
- W4220819374 cites W1987816685 @default.
- W4220819374 cites W1990705170 @default.
- W4220819374 cites W1990955455 @default.
- W4220819374 cites W1995166771 @default.
- W4220819374 cites W1998813486 @default.
- W4220819374 cites W2001747259 @default.
- W4220819374 cites W2003739799 @default.
- W4220819374 cites W2005033167 @default.
- W4220819374 cites W2010243889 @default.
- W4220819374 cites W2013302784 @default.
- W4220819374 cites W2019140289 @default.
- W4220819374 cites W2021123891 @default.
- W4220819374 cites W2039780464 @default.
- W4220819374 cites W2041740456 @default.
- W4220819374 cites W2042122892 @default.
- W4220819374 cites W2060287015 @default.
- W4220819374 cites W2062835892 @default.
- W4220819374 cites W2064550455 @default.
- W4220819374 cites W2065140692 @default.
- W4220819374 cites W2066339876 @default.
- W4220819374 cites W2067545795 @default.
- W4220819374 cites W2070105714 @default.
- W4220819374 cites W2074465835 @default.
- W4220819374 cites W2079332279 @default.
- W4220819374 cites W2079815081 @default.
- W4220819374 cites W2082319957 @default.
- W4220819374 cites W2083442454 @default.
- W4220819374 cites W2089453874 @default.
- W4220819374 cites W2094148186 @default.
- W4220819374 cites W2096716204 @default.
- W4220819374 cites W2098654083 @default.
- W4220819374 cites W2105257219 @default.
- W4220819374 cites W2105327109 @default.
- W4220819374 cites W2110459971 @default.
- W4220819374 cites W2111063688 @default.
- W4220819374 cites W2115948141 @default.
- W4220819374 cites W2116712105 @default.
- W4220819374 cites W2116794323 @default.
- W4220819374 cites W2125505483 @default.
- W4220819374 cites W2129379280 @default.
- W4220819374 cites W2130655121 @default.
- W4220819374 cites W2135050229 @default.
- W4220819374 cites W2140409748 @default.
- W4220819374 cites W2158591358 @default.
- W4220819374 cites W2171809815 @default.
- W4220819374 cites W2174560499 @default.
- W4220819374 cites W2177651241 @default.
- W4220819374 cites W2319809815 @default.
- W4220819374 cites W2465612254 @default.
- W4220819374 cites W2511724056 @default.
- W4220819374 cites W2532018695 @default.
- W4220819374 cites W253358839 @default.
- W4220819374 cites W2547339822 @default.
- W4220819374 cites W2568502424 @default.
- W4220819374 cites W2724496531 @default.
- W4220819374 cites W2736716929 @default.
- W4220819374 cites W2737868829 @default.
- W4220819374 cites W2754423591 @default.
- W4220819374 cites W2761443831 @default.
- W4220819374 cites W2762418691 @default.
- W4220819374 cites W2762453060 @default.
- W4220819374 cites W2763252130 @default.
- W4220819374 cites W2767678580 @default.
- W4220819374 cites W2774586064 @default.
- W4220819374 cites W2790678433 @default.
- W4220819374 cites W2793557865 @default.
- W4220819374 cites W2795539529 @default.
- W4220819374 cites W2805529518 @default.
- W4220819374 cites W2808305854 @default.
- W4220819374 cites W2809675229 @default.
- W4220819374 cites W2809868132 @default.
- W4220819374 cites W2898489319 @default.
- W4220819374 cites W2899483281 @default.
- W4220819374 cites W2899650821 @default.
- W4220819374 cites W2904351369 @default.
- W4220819374 cites W2906125619 @default.
- W4220819374 cites W2945404218 @default.