FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220821552> ?p ?o ?g. }

• W4220821552 endingPage "342" @default.
• W4220821552 startingPage "342" @default.
• W4220821552 abstract "Optimization of antimicrobial treatment during a bacterial infection in livestock requires in-depth knowledge of the impact of antimicrobial therapy on the pathogen and commensal microbiota. Once administered antimicrobials and/or their metabolites are excreted either by the kidneys through urine and/or by the intestinal tract through feces, causing antimicrobial pressure and possibly the emergence of resistance in the gastro-intestinal tract. So far, the excretion of ceftiofur and cefquinome in the intestinal tract of pigs has not been described. The objective of this study was to investigate the excretion of ceftiofur and cefquinome in the different segments of the gut and feces after intramuscular administration. Therefore, 16 pigs were treated either with ceftiofur (n = 8) or cefquinome (n = 8), and feces were collected during the entire treatment period. The presence of ceftiofur and desfuroylceftiofuracetamide or cefquinome were quantified via liquid chromatography−tandem mass spectrometry. At the end of the treatment, pigs were euthanized, and samples from the duodenum, jejunum, ileum and cecum were analyzed. In feces, no active antimicrobial residues could be measured, except for one ceftiofur-treated pig. In the gut segments, the concentration of both antimicrobials increased from duodenum toward the ileum, with a maximum in the ileum (187.8 ± 101.7 ng·g−1 ceftiofur-related residues, 57.8 ± 37.5 ng·g−1 cefquinome) and sharply decreased in the cecum (below the limit of quantification for ceftiofur-related residues, 6.4 ± 4.2 ng·g−1 cefquinome). Additionally, long-read Nanopore sequencing and targeted quantitative polymerase chain reaction (qPCR) were performed in an attempt to clarify the discrepancy in fecal excretion of ceftiofur-related residues between pigs. In general, there was an increase in Prevotella, Bacteroides and Faecalibacterium and a decrease in Escherichia and Clostridium after ceftiofur administration (q-value < 0.05). The sequencing and qPCR could not provide an explanation for the unexpected excretion of ceftiofur-related residues in one pig out of eight. Overall, this study provides valuable information on the gut excretion of parenteral administered ceftiofur and cefquinome." @default.
• W4220821552 created "2022-04-03" @default.
• W4220821552 creator A5006530143 @default.
• W4220821552 creator A5032893370 @default.
• W4220821552 creator A5040932514 @default.
• W4220821552 creator A5064725360 @default.
• W4220821552 creator A5084656029 @default.
• W4220821552 date "2022-03-04" @default.
• W4220821552 modified "2023-10-14" @default.
• W4220821552 title "Intestinal Exposure to Ceftiofur and Cefquinome after Intramuscular Treatment and the Impact of Ceftiofur on the Pig Fecal Microbiome and Resistome" @default.
• W4220821552 cites W1519572055 @default.
• W4220821552 cites W1912578996 @default.
• W4220821552 cites W1915924919 @default.
• W4220821552 cites W1922476981 @default.
• W4220821552 cites W1926318014 @default.
• W4220821552 cites W1964812044 @default.
• W4220821552 cites W1970162220 @default.
• W4220821552 cites W1970400998 @default.
• W4220821552 cites W1975261137 @default.
• W4220821552 cites W1979535577 @default.
• W4220821552 cites W1980863376 @default.
• W4220821552 cites W2011223551 @default.
• W4220821552 cites W2020170281 @default.
• W4220821552 cites W2025774007 @default.
• W4220821552 cites W2029989660 @default.
• W4220821552 cites W2033617629 @default.
• W4220821552 cites W2035389098 @default.
• W4220821552 cites W2040834403 @default.
• W4220821552 cites W2043432167 @default.
• W4220821552 cites W2061606889 @default.
• W4220821552 cites W2070313657 @default.
• W4220821552 cites W2071606198 @default.
• W4220821552 cites W2072417345 @default.
• W4220821552 cites W2073797258 @default.
• W4220821552 cites W2074604023 @default.
• W4220821552 cites W2077283981 @default.
• W4220821552 cites W2078365477 @default.
• W4220821552 cites W2085691101 @default.
• W4220821552 cites W2094111345 @default.
• W4220821552 cites W2105580456 @default.
• W4220821552 cites W2111816131 @default.
• W4220821552 cites W2115382007 @default.
• W4220821552 cites W2117464052 @default.
• W4220821552 cites W2118597638 @default.
• W4220821552 cites W2127072069 @default.
• W4220821552 cites W2128743925 @default.
• W4220821552 cites W2133428211 @default.
• W4220821552 cites W2134985690 @default.
• W4220821552 cites W2137487130 @default.
• W4220821552 cites W2139672978 @default.
• W4220821552 cites W2142169580 @default.
• W4220821552 cites W2146651683 @default.
• W4220821552 cites W2147527718 @default.
• W4220821552 cites W2154171904 @default.
• W4220821552 cites W2167179929 @default.
• W4220821552 cites W2294145430 @default.
• W4220821552 cites W2411748336 @default.
• W4220821552 cites W2487144347 @default.
• W4220821552 cites W2544493586 @default.
• W4220821552 cites W2611223559 @default.
• W4220821552 cites W2775417423 @default.
• W4220821552 cites W2790145753 @default.
• W4220821552 cites W2790883564 @default.
• W4220821552 cites W2791063454 @default.
• W4220821552 cites W2795582164 @default.
• W4220821552 cites W2799572541 @default.
• W4220821552 cites W2806362852 @default.
• W4220821552 cites W2848657672 @default.
• W4220821552 cites W2887509155 @default.
• W4220821552 cites W2902969697 @default.
• W4220821552 cites W2911810152 @default.
• W4220821552 cites W2922431493 @default.
• W4220821552 cites W2942123375 @default.
• W4220821552 cites W2945765942 @default.
• W4220821552 cites W2947111272 @default.
• W4220821552 cites W2951278111 @default.
• W4220821552 cites W2977399267 @default.
• W4220821552 cites W2990618091 @default.
• W4220821552 cites W2990913009 @default.
• W4220821552 cites W2996102122 @default.
• W4220821552 cites W3045021857 @default.
• W4220821552 cites W3047226298 @default.
• W4220821552 cites W3163486704 @default.
• W4220821552 cites W3178630568 @default.
• W4220821552 cites W3186125547 @default.
• W4220821552 cites W4206512490 @default.
• W4220821552 cites W978820695 @default.
• W4220821552 cites W2900378413 @default.
• W4220821552 doi "https://doi.org/10.3390/antibiotics11030342" @default.
• W4220821552 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35326805" @default.
• W4220821552 hasPublicationYear "2022" @default.
• W4220821552 type Work @default.
• W4220821552 citedByCount "2" @default.
• W4220821552 countsByYear W42208215522023 @default.
• W4220821552 crossrefType "journal-article" @default.
• W4220821552 hasAuthorship W4220821552A5006530143 @default.
• W4220821552 hasAuthorship W4220821552A5032893370 @default.
• W4220821552 hasAuthorship W4220821552A5040932514 @default.

• next