FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220822568> ?p ?o ?g. }

• W4220822568 endingPage "10" @default.
• W4220822568 startingPage "1" @default.
• W4220822568 abstract "To investigate the effect of 2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside (TSG) on the osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) and its molecular mechanism.After TSG treatment of rBMSCs, alkaline phosphatase (ALP) activity was compared between the drug treatment group and the control group. The effects of TSG on alkaline phosphatase positive cloning and mineralized nodule formation were also detected. Total mRNA and protein were extracted, and the effects of TSG on the expression levels of osteopontin (OPN), osteocalcin (OCN), Runt-related transcription factor 2 (Runx2), Osterix, and Col1a1 were detected by real-time fluorescence quantitative PCR. Western blotting was used to detect the inhibitory effect of TSG on KDM5A. BMSCs were transfected with small interfering RNA (siRNA) targeting KDM5A (si-KMD5A) and pcDNA3.1 KMD5A.TSG significantly increased the activity of ALP, the number of alkaline phosphatase clones, and calcified nodule formation. The OPN, OCN, Runx2, and Osterix expression levels were significantly increased among the osteoblasts after TSG treatment. A mechanistic study showed that the effect of TSG is realized by inhibiting KDM5A.KDM5A signaling may be involved in the regulation of osteogenic differentiation of rBMSCs. TSG can promote osteogenic differentiation and maturation of rBMSCs at 0.1-50 μmol/L. The mechanism of action was realized by inhibiting the expression of KDM5A." @default.
• W4220822568 created "2022-04-03" @default.
• W4220822568 creator A5003190764 @default.
• W4220822568 creator A5029669995 @default.
• W4220822568 creator A5078335216 @default.
• W4220822568 date "2022-01-25" @default.
• W4220822568 modified "2023-09-26" @default.
• W4220822568 title "TSG Targeting KDM5A Affects Osteogenic Differentiation of Bone Mesenchymal Stem Cells Induced by Bone Morphogenetic Protein 2" @default.
• W4220822568 cites W1984066790 @default.
• W4220822568 cites W1990792003 @default.
• W4220822568 cites W1991554693 @default.
• W4220822568 cites W1992104196 @default.
• W4220822568 cites W1998650056 @default.
• W4220822568 cites W2008284137 @default.
• W4220822568 cites W2018483711 @default.
• W4220822568 cites W2018950607 @default.
• W4220822568 cites W2031108668 @default.
• W4220822568 cites W2036994679 @default.
• W4220822568 cites W2046695171 @default.
• W4220822568 cites W2053852292 @default.
• W4220822568 cites W2054848478 @default.
• W4220822568 cites W2070000741 @default.
• W4220822568 cites W2075552693 @default.
• W4220822568 cites W2077510301 @default.
• W4220822568 cites W2083601541 @default.
• W4220822568 cites W2100377809 @default.
• W4220822568 cites W2154234231 @default.
• W4220822568 cites W2160871558 @default.
• W4220822568 cites W2326047596 @default.
• W4220822568 cites W2520906511 @default.
• W4220822568 cites W2767246312 @default.
• W4220822568 cites W2889367547 @default.
• W4220822568 cites W2909682180 @default.
• W4220822568 doi "https://doi.org/10.1155/2022/6472864" @default.
• W4220822568 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35126937" @default.
• W4220822568 hasPublicationYear "2022" @default.
• W4220822568 type Work @default.
• W4220822568 citedByCount "0" @default.
• W4220822568 crossrefType "journal-article" @default.
• W4220822568 hasAuthorship W4220822568A5003190764 @default.
• W4220822568 hasAuthorship W4220822568A5029669995 @default.
• W4220822568 hasAuthorship W4220822568A5078335216 @default.
• W4220822568 hasBestOaLocation W42208225681 @default.
• W4220822568 hasConcept C104317684 @default.
• W4220822568 hasConcept C131075544 @default.
• W4220822568 hasConcept C148738053 @default.
• W4220822568 hasConcept C153911025 @default.
• W4220822568 hasConcept C160160445 @default.
• W4220822568 hasConcept C181199279 @default.
• W4220822568 hasConcept C185592680 @default.
• W4220822568 hasConcept C198826908 @default.
• W4220822568 hasConcept C202751555 @default.
• W4220822568 hasConcept C203014093 @default.
• W4220822568 hasConcept C22615655 @default.
• W4220822568 hasConcept C2776363554 @default.
• W4220822568 hasConcept C2776432469 @default.
• W4220822568 hasConcept C2780804394 @default.
• W4220822568 hasConcept C30352789 @default.
• W4220822568 hasConcept C31507581 @default.
• W4220822568 hasConcept C54009773 @default.
• W4220822568 hasConcept C55493867 @default.
• W4220822568 hasConcept C85265743 @default.
• W4220822568 hasConcept C86803240 @default.
• W4220822568 hasConcept C95444343 @default.
• W4220822568 hasConceptScore W4220822568C104317684 @default.
• W4220822568 hasConceptScore W4220822568C131075544 @default.
• W4220822568 hasConceptScore W4220822568C148738053 @default.
• W4220822568 hasConceptScore W4220822568C153911025 @default.
• W4220822568 hasConceptScore W4220822568C160160445 @default.
• W4220822568 hasConceptScore W4220822568C181199279 @default.
• W4220822568 hasConceptScore W4220822568C185592680 @default.
• W4220822568 hasConceptScore W4220822568C198826908 @default.
• W4220822568 hasConceptScore W4220822568C202751555 @default.
• W4220822568 hasConceptScore W4220822568C203014093 @default.
• W4220822568 hasConceptScore W4220822568C22615655 @default.
• W4220822568 hasConceptScore W4220822568C2776363554 @default.
• W4220822568 hasConceptScore W4220822568C2776432469 @default.
• W4220822568 hasConceptScore W4220822568C2780804394 @default.
• W4220822568 hasConceptScore W4220822568C30352789 @default.
• W4220822568 hasConceptScore W4220822568C31507581 @default.
• W4220822568 hasConceptScore W4220822568C54009773 @default.
• W4220822568 hasConceptScore W4220822568C55493867 @default.
• W4220822568 hasConceptScore W4220822568C85265743 @default.
• W4220822568 hasConceptScore W4220822568C86803240 @default.
• W4220822568 hasConceptScore W4220822568C95444343 @default.
• W4220822568 hasFunder F4320321001 @default.
• W4220822568 hasLocation W42208225681 @default.
• W4220822568 hasLocation W42208225682 @default.
• W4220822568 hasLocation W42208225683 @default.
• W4220822568 hasLocation W42208225684 @default.
• W4220822568 hasLocation W42208225685 @default.
• W4220822568 hasOpenAccess W4220822568 @default.
• W4220822568 hasPrimaryLocation W42208225681 @default.
• W4220822568 hasRelatedWork W1964791192 @default.
• W4220822568 hasRelatedWork W2047790628 @default.
• W4220822568 hasRelatedWork W2073552867 @default.
• W4220822568 hasRelatedWork W2135540314 @default.
• W4220822568 hasRelatedWork W2160969595 @default.

• next