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• W4220822912 endingPage "1345" @default.
• W4220822912 startingPage "1345" @default.
• W4220822912 abstract "Protein kinases of the Casein Kinase 1 family play a vital role in the regulation of numerous cellular processes. Apart from functions associated with regulation of proliferation, differentiation, or apoptosis, localization of several Casein Kinase 1 isoforms to the centrosome and microtubule asters also implicates regulatory functions in microtubule dynamic processes. Being localized to the spindle apparatus during mitosis Casein Kinase 1 directly modulates microtubule dynamics by phosphorylation of tubulin isoforms. Additionally, site-specific phosphorylation of microtubule-associated proteins can be related to the maintenance of genomic stability but also microtubule stabilization/destabilization, e.g., by hyper-phosphorylation of microtubule-associated protein 1A and RITA1. Consequently, approaches interfering with Casein Kinase 1-mediated microtubule-specific functions might be exploited as therapeutic strategies for the treatment of cancer. Currently pursued strategies include the development of Casein Kinase 1 isoform-specific small molecule inhibitors and therapeutically useful peptides specifically inhibiting kinase-substrate interactions." @default.
• W4220822912 created "2022-04-03" @default.
• W4220822912 creator A5005097370 @default.
• W4220822912 creator A5005744786 @default.
• W4220822912 creator A5055339113 @default.
• W4220822912 creator A5064731771 @default.
• W4220822912 creator A5075437310 @default.
• W4220822912 creator A5085743311 @default.
• W4220822912 date "2022-03-05" @default.
• W4220822912 modified "2023-10-16" @default.
• W4220822912 title "CK1 Is a Druggable Regulator of Microtubule Dynamics and Microtubule-Associated Processes" @default.
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