FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220824648> ?p ?o ?g. }

• W4220824648 abstract "Cilia are ubiquitous and highly conserved extensions that endow the cell with motility and sensory functions. They were present in the first eukaryotes and conserved throughout evolution (Carvalho-Santos et al., 2011). Paramecium has around 4,000 motile cilia on its surface arranged in longitudinal rows, beating in waves to ensure movement and feeding. As with cilia in other model organisms, direction and speed of Paramecium ciliary beating is under bioelectric control of ciliary ion channels. In multiciliated cells of metazoans as well as paramecia, the cilia become physically entrained to beat in metachronal waves. This ciliated organism, Paramecium, is an attractive model for multidisciplinary approaches to dissect the location, structure and function of ciliary ion channels and other proteins involved in ciliary beating. Swimming behavior also can be a read-out of the role of cilia in sensory signal transduction. A cilium emanates from a BB, structurally equivalent to the centriole anchored at the cell surface, and elongates an axoneme composed of microtubule doublets enclosed in a ciliary membrane contiguous with the plasma membrane. The connection between the BB and the axoneme constitutes the transition zone, which serves as a diffusion barrier between the intracellular space and the cilium, defining the ciliary compartment. Human pathologies affecting cilia structure or function, are called ciliopathies, which are caused by gene mutations. For that reason, the molecular mechanisms and structural aspects of cilia assembly and function are actively studied using a variety of model systems, ranging from unicellular organisms to metazoa. In this review, we will highlight the use of Paramecium as a model to decipher ciliary beating mechanisms as well as high resolution insights into BB structure and anchoring. We will show that study of cilia in Paramecium promotes our understanding of cilia formation and function. In addition, we demonstrate that Paramecium could be a useful tool to validate candidate genes for ciliopathies." @default.
• W4220824648 created "2022-04-03" @default.
• W4220824648 creator A5000965716 @default.
• W4220824648 creator A5028985019 @default.
• W4220824648 creator A5031888083 @default.
• W4220824648 creator A5042638968 @default.
• W4220824648 creator A5049475945 @default.
• W4220824648 creator A5055745495 @default.
• W4220824648 creator A5059627808 @default.
• W4220824648 creator A5067328844 @default.
• W4220824648 creator A5086063829 @default.
• W4220824648 date "2022-03-14" @default.
• W4220824648 modified "2023-10-16" @default.
• W4220824648 title "Paramecium, a Model to Study Ciliary Beating and Ciliogenesis: Insights From Cutting-Edge Approaches" @default.
• W4220824648 cites W1035909416 @default.
• W4220824648 cites W1139666121 @default.
• W4220824648 cites W1524874101 @default.
• W4220824648 cites W1548143133 @default.
• W4220824648 cites W1579954330 @default.
• W4220824648 cites W1885365076 @default.
• W4220824648 cites W1954800703 @default.
• W4220824648 cites W1963552271 @default.
• W4220824648 cites W1966509422 @default.
• W4220824648 cites W1968830789 @default.
• W4220824648 cites W1973420993 @default.
• W4220824648 cites W1977202492 @default.
• W4220824648 cites W1977207226 @default.
• W4220824648 cites W1977264068 @default.
• W4220824648 cites W1983811433 @default.
• W4220824648 cites W1986836721 @default.
• W4220824648 cites W1987129763 @default.
• W4220824648 cites W1990053445 @default.
• W4220824648 cites W1992717591 @default.
• W4220824648 cites W1993690386 @default.
• W4220824648 cites W1994138491 @default.
• W4220824648 cites W1995071192 @default.
• W4220824648 cites W1996362985 @default.
• W4220824648 cites W1996479070 @default.
• W4220824648 cites W1997364113 @default.
• W4220824648 cites W2001131984 @default.
• W4220824648 cites W2005647411 @default.
• W4220824648 cites W2007154196 @default.
• W4220824648 cites W2010490709 @default.
• W4220824648 cites W2012931395 @default.
• W4220824648 cites W2014264816 @default.
• W4220824648 cites W2016400146 @default.
• W4220824648 cites W2022387954 @default.
• W4220824648 cites W2023496937 @default.
• W4220824648 cites W2027637814 @default.
• W4220824648 cites W2033799316 @default.
• W4220824648 cites W2043058919 @default.
• W4220824648 cites W2044212724 @default.
• W4220824648 cites W2049460100 @default.
• W4220824648 cites W2055090638 @default.
• W4220824648 cites W2056007090 @default.
• W4220824648 cites W2058041132 @default.
• W4220824648 cites W2058771131 @default.
• W4220824648 cites W2064907366 @default.
• W4220824648 cites W2066105154 @default.
• W4220824648 cites W2069073162 @default.
• W4220824648 cites W2069640032 @default.
• W4220824648 cites W2071146817 @default.
• W4220824648 cites W2073111128 @default.
• W4220824648 cites W2073767131 @default.
• W4220824648 cites W2074014198 @default.
• W4220824648 cites W2077090337 @default.
• W4220824648 cites W2077587895 @default.
• W4220824648 cites W2084567732 @default.
• W4220824648 cites W2088290371 @default.
• W4220824648 cites W2090532223 @default.
• W4220824648 cites W2091650667 @default.
• W4220824648 cites W2094954172 @default.
• W4220824648 cites W2096025827 @default.
• W4220824648 cites W2096369882 @default.
• W4220824648 cites W2100202535 @default.
• W4220824648 cites W2106024132 @default.
• W4220824648 cites W2108062949 @default.
• W4220824648 cites W2110354117 @default.
• W4220824648 cites W2110751622 @default.
• W4220824648 cites W2114863423 @default.
• W4220824648 cites W2118305720 @default.
• W4220824648 cites W2122190658 @default.
• W4220824648 cites W2128508997 @default.
• W4220824648 cites W2131923709 @default.
• W4220824648 cites W2132840587 @default.
• W4220824648 cites W2133910881 @default.
• W4220824648 cites W2138310216 @default.
• W4220824648 cites W2138817668 @default.
• W4220824648 cites W2141983754 @default.
• W4220824648 cites W2147861622 @default.
• W4220824648 cites W2160793554 @default.
• W4220824648 cites W2161570516 @default.
• W4220824648 cites W2164286085 @default.
• W4220824648 cites W2165851239 @default.
• W4220824648 cites W2167859555 @default.
• W4220824648 cites W2173763706 @default.
• W4220824648 cites W2175322800 @default.
• W4220824648 cites W2176112947 @default.
• W4220824648 cites W2285524619 @default.
• W4220824648 cites W2294781973 @default.

• next