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• W4220826326 endingPage "396" @default.
• W4220826326 startingPage "377" @default.
• W4220826326 abstract "The mayhem COVID-19 that was ushered by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) was declared pandemic by the World Health Organization in March 2020. Since its initial outbreak in late 2019, the virus has affected hundreds of million adults in the world and killing millions in the process. After the approval of newly developed vaccines, severe challenges remain to manufacture and administer them to the adult population globally in quick time. However, we have witnessed several mutations of the virus leading to 'waves' of viral spread and mortality. WHO has categorized these mutations as variants of concern (VOCs) and variants of interest (VOIs). The mortality due to COVID-19 has also been associated with various comorbidities and improper immune response. This has created further complications in understanding the nature of the SARS-CoV2-host interaction that has fuelled doubts in the efficacy of the approved vaccines. Whether there is requirement of booster dose and whether the impending wave could affect the children are some of the hotly debated topics.A systematic literature review of PubMed, Medline, Scopus, Google Scholar was utilized to understand the nature of Delta variant and how it alters our T-cell responses and cytokine production and neutralizes vaccine-generated antibodies.In this review, we discuss the variants of SARS-CoV2 with specific focus on the Delta variant. We also specifically review the T-cell response against the virus and bring a narrative of various factors that may hold the key to fight against this marauding virus." @default.
• W4220826326 created "2022-04-03" @default.
• W4220826326 creator A5020430471 @default.
• W4220826326 creator A5032108772 @default.
• W4220826326 creator A5071274971 @default.
• W4220826326 creator A5071713023 @default.
• W4220826326 creator A5089997460 @default.
• W4220826326 date "2022-03-15" @default.
• W4220826326 modified "2023-09-26" @default.
• W4220826326 title "COVID-19 pandemic: the delta variant, T-cell responses, and the efficacy of developing vaccines" @default.
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