FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220826972> ?p ?o ?g. }

• W4220826972 abstract "Cyclin C (CCNC) was reported to take part in regulating mitochondria-derived oxidative stress under cisplatin stimulation. However, its effect in gastric cancer is unknown. This study aimed to investigate the role of cyclin C and its ubiquitylation in regulating cisplatin resistance in gastric cancer.The interaction between HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase 1 (HACE1) and cyclin C was investigated by GST pull-down assay, co-immunoprecipitation and ubiquitylation assay. Mitochondria-derived oxidative stress was studied by MitoSOX Red assay, seahorse assay and mitochondrial membrane potential measurement. Cyclin C-associated cisplatin resistance was studied in vivo via xenograft.HACE1 catalysed the ubiquitylation of cyclin C by adding Lys11-linked ubiquitin chains when cyclin C translocates to cytoplasm induced by cisplatin treatment. The ubiquitin-modified cyclin C then anchor at mitochondira, which induced mitochondrial fission and ROS synthesis. Depleting CCNC or mutation on the ubiquitylation sites decreased mitochondrial ROS production and reduced cell apoptosis under cisplatin treatment. Xenograft study showed that disrupting cyclin C ubiquitylation by HACE1 conferred impairing cell apoptosis response upon cisplatin administration.Cyclin C is a newly identified substrate of HACE1 E3 ligase. HACE1-mediated ubiquitylation of cyclin C sheds light on a better understanding of cisplatin-associated resistance in gastric cancer patients. Ubiquitylation of cyclin C by HACE1 regulates cisplatin-associated sensitivity in gastric cancer. With cisplatin-induced nuclear-mitochondrial translocation of cyclin C, its ubiquitylation by HACE1 increased mitochondrial fission and mitochondrial-derived oxidative stress, leading to cell apoptosis." @default.
• W4220826972 created "2022-04-03" @default.
• W4220826972 creator A5011541550 @default.
• W4220826972 creator A5013608655 @default.
• W4220826972 creator A5028179414 @default.
• W4220826972 creator A5043206919 @default.
• W4220826972 creator A5053912557 @default.
• W4220826972 creator A5057966896 @default.
• W4220826972 creator A5061402622 @default.
• W4220826972 creator A5073021091 @default.
• W4220826972 date "2022-03-01" @default.
• W4220826972 modified "2023-10-16" @default.
• W4220826972 title "Ubiquitylation of cyclin C by HACE1 regulates cisplatin‐associated sensitivity in gastric cancer" @default.
• W4220826972 cites W1245662471 @default.
• W4220826972 cites W1960421135 @default.
• W4220826972 cites W1963967499 @default.
• W4220826972 cites W1978580147 @default.
• W4220826972 cites W1990171977 @default.
• W4220826972 cites W1991861746 @default.
• W4220826972 cites W2005757378 @default.
• W4220826972 cites W2015683487 @default.
• W4220826972 cites W2029081769 @default.
• W4220826972 cites W2036176224 @default.
• W4220826972 cites W2039407031 @default.
• W4220826972 cites W2040087322 @default.
• W4220826972 cites W2106453983 @default.
• W4220826972 cites W2135028625 @default.
• W4220826972 cites W2136128861 @default.
• W4220826972 cites W2143538182 @default.
• W4220826972 cites W2155304845 @default.
• W4220826972 cites W2155504233 @default.
• W4220826972 cites W2155588015 @default.
• W4220826972 cites W2157334943 @default.
• W4220826972 cites W2166732319 @default.
• W4220826972 cites W2231663276 @default.
• W4220826972 cites W2274595380 @default.
• W4220826972 cites W2277306200 @default.
• W4220826972 cites W2297008679 @default.
• W4220826972 cites W2346363069 @default.
• W4220826972 cites W2463600666 @default.
• W4220826972 cites W2541053115 @default.
• W4220826972 cites W2599936639 @default.
• W4220826972 cites W2737785069 @default.
• W4220826972 cites W2762198049 @default.
• W4220826972 cites W2766976376 @default.
• W4220826972 cites W2794403904 @default.
• W4220826972 cites W2800432457 @default.
• W4220826972 cites W2903091755 @default.
• W4220826972 cites W2908302029 @default.
• W4220826972 cites W2909460864 @default.
• W4220826972 cites W2910456696 @default.
• W4220826972 cites W2917837889 @default.
• W4220826972 cites W2942618350 @default.
• W4220826972 cites W2964567283 @default.
• W4220826972 cites W2969669884 @default.
• W4220826972 cites W3013764432 @default.
• W4220826972 cites W3097678413 @default.
• W4220826972 cites W3120731431 @default.
• W4220826972 cites W3120866366 @default.
• W4220826972 cites W3125796414 @default.
• W4220826972 cites W4210757594 @default.
• W4220826972 cites W4242151806 @default.
• W4220826972 doi "https://doi.org/10.1002/ctm2.770" @default.
• W4220826972 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35343092" @default.
• W4220826972 hasPublicationYear "2022" @default.
• W4220826972 type Work @default.
• W4220826972 citedByCount "5" @default.
• W4220826972 countsByYear W42208269722022 @default.
• W4220826972 countsByYear W42208269722023 @default.
• W4220826972 crossrefType "journal-article" @default.
• W4220826972 hasAuthorship W4220826972A5011541550 @default.
• W4220826972 hasAuthorship W4220826972A5013608655 @default.
• W4220826972 hasAuthorship W4220826972A5028179414 @default.
• W4220826972 hasAuthorship W4220826972A5043206919 @default.
• W4220826972 hasAuthorship W4220826972A5053912557 @default.
• W4220826972 hasAuthorship W4220826972A5057966896 @default.
• W4220826972 hasAuthorship W4220826972A5061402622 @default.
• W4220826972 hasAuthorship W4220826972A5073021091 @default.
• W4220826972 hasBestOaLocation W42208269722 @default.
• W4220826972 hasConcept C104317684 @default.
• W4220826972 hasConcept C11882975 @default.
• W4220826972 hasConcept C134459356 @default.
• W4220826972 hasConcept C153911025 @default.
• W4220826972 hasConcept C16438837 @default.
• W4220826972 hasConcept C185592680 @default.
• W4220826972 hasConcept C190283241 @default.
• W4220826972 hasConcept C199835354 @default.
• W4220826972 hasConcept C25602115 @default.
• W4220826972 hasConcept C2776694085 @default.
• W4220826972 hasConcept C2778239845 @default.
• W4220826972 hasConcept C28179978 @default.
• W4220826972 hasConcept C29537977 @default.
• W4220826972 hasConcept C502942594 @default.
• W4220826972 hasConcept C54355233 @default.
• W4220826972 hasConcept C55493867 @default.
• W4220826972 hasConcept C86803240 @default.
• W4220826972 hasConcept C95444343 @default.
• W4220826972 hasConceptScore W4220826972C104317684 @default.
• W4220826972 hasConceptScore W4220826972C11882975 @default.
• W4220826972 hasConceptScore W4220826972C134459356 @default.

• next