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- W4220830071 abstract "Bone exhibits remarkable self-repair ability without fibrous scars. It is believed that the robust regenerative capacity comes from tissue-resident stem cells, such as skeletal stem cells (SSCs). Roughly, SSC has two niches: bone marrow (BM) and periosteum. BM-SSCs have been extensively studied for years. In contrast, our knowledge about periosteal SSCs (P-SSCs) is quite limited. There is abundant clinical evidence for the presence of stem cell populations within the periosteum. Researchers have even successfully cultured stem-like cells from the periosteum in vitro. However, due to the lack of effective markers, it is difficult to evaluate the stemness of real P-SSCs in vivo. Recently, several research teams have developed strategies for the successful identification of P-SSCs. For the first time, we can assess the stemness of P-SSCs from visual evidence. BM-SSCs and P-SSCs not only have much in common but also share distinct properties. Here, we provide an updated review of P-SSCs and their particular responses to bone injury." @default.
- W4220830071 created "2022-04-03" @default.
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- W4220830071 date "2022-03-24" @default.
- W4220830071 modified "2023-10-18" @default.
- W4220830071 title "Periosteal Skeletal Stem Cells and Their Response to Bone Injury" @default.
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- W4220830071 doi "https://doi.org/10.3389/fcell.2022.812094" @default.
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