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- W4220831711 abstract "Purpose of review The purpose of this update is to summarize current knowledge on the pathophysiology of immunglobulin A (IgA) vasculitis nephritis (IgAVN) as well as to critically review evidence for established therapeutic regimes and available biomarkers. An additional purpose is to raise the discussion what could be done to further improve our understanding of IgAVN, identify patients at risk for adverse outcome and increase the evidence for therapy recommendations. Recent findings Clinical and experimental studies have established the concept of a multilevel pathogenesis. Toll-like-receptor activation, B cell proliferation, micro-RNAs and complement activation have been identified or confirmed as potential therapeutic targets which can modify the course of the disease. Currently, kidney injury molecule-1, monocyte chemotactic protein-1, N-acetyl-β-glucosaminidase, and angiotensinogen are the most promising urinary biomarkers for early diagnosis of renal involvement in IgA vasculitis. Summary Close surveillance of all IgAV patients for renal involvement is recommended. Given the multilevel pathogenesis, early treatment of even mild cases should be initiated. Further therapeutic options should be considered in case first-line therapy (mostly corticosteroids) has no effect. The evidence supporting current therapeutic regimes is predominantly based on expert opinion. Prospective studies are needed and should involve substances inhibiting B cell proliferation and complement activation." @default.
- W4220831711 created "2022-04-03" @default.
- W4220831711 creator A5012572131 @default.
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- W4220831711 date "2022-02-07" @default.
- W4220831711 modified "2023-10-18" @default.
- W4220831711 title "IgA vasculitis nephritis" @default.
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- W4220831711 cites W2101932247 @default.
- W4220831711 cites W2125388878 @default.
- W4220831711 cites W2132740030 @default.
- W4220831711 cites W2154834722 @default.
- W4220831711 cites W2181240763 @default.
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- W4220831711 cites W2328548852 @default.
- W4220831711 cites W2560062901 @default.
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- W4220831711 cites W2770541118 @default.
- W4220831711 cites W2887265391 @default.
- W4220831711 cites W2899995215 @default.
- W4220831711 cites W2921383353 @default.
- W4220831711 cites W2925994359 @default.
- W4220831711 cites W2929806984 @default.
- W4220831711 cites W2939625028 @default.
- W4220831711 cites W2939741213 @default.
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- W4220831711 cites W2949586241 @default.
- W4220831711 cites W2956142215 @default.
- W4220831711 cites W2964353829 @default.
- W4220831711 cites W2966756304 @default.
- W4220831711 cites W2969644909 @default.
- W4220831711 cites W2969668837 @default.
- W4220831711 cites W2970501086 @default.
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- W4220831711 cites W3006646555 @default.
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- W4220831711 doi "https://doi.org/10.1097/mop.0000000000001120" @default.
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