Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220832005> ?p ?o ?g. }
- W4220832005 endingPage "737" @default.
- W4220832005 startingPage "726" @default.
- W4220832005 abstract "Epilepsy is a neurological disease that pathologically affects brain functions. The epileptic hippocampus has modified microRNA(miRNA) levels. Therefore, we aimed to evaluate the neuroprotective effect of thymoquinone (TQ) in PTZ-induced epilepsy and to demonstrate the overlap between miRNA and mRNA expression profiles.Male adult Wistar albino rats (200-230 g, n = 20) were divided into three groups as control (n = 6), PTZ (n = 7), and TQ + PTZ (n = 7). The PTZ kindling model was created by injecting PTZ in sub convulsive doses to rats on days 1, 3, 5, 8, 10, 12, 15, 17, 19, 22, and 24 of the study into animals. Clonic and tonic seizures were induced by injecting a convulsive dose of PTZ on day 26 of the study. Rats in the TQ+PTZ group were treated by oral gavage with a 20 mg/kg TQ 2 h before each PTZ injection. The rats in the control group were treated with 0.5 ml saline. Seizure severity was evaluated with the Racine scale. The genes and signaling pathways targeted by miRNAs were determined by bioinformatics analysis.In the rat hippocampus, mature 728 miRNAs were analyzed by microarray and the nine miRNA were verified by quantitative Real-Time PCR. rno-miR-182 and rno-miR-27b-3p were up-regulated in the PTZ group and down-regulated in the TQ + PTZ group.In the PTZ kindling epilepsy model, the expression of these two miRNAs was regulated by TQ and exerted a neuroprotective effect by controlling the activities of target genes." @default.
- W4220832005 created "2022-04-03" @default.
- W4220832005 creator A5017052920 @default.
- W4220832005 creator A5033832274 @default.
- W4220832005 creator A5041317514 @default.
- W4220832005 creator A5073706436 @default.
- W4220832005 creator A5074520805 @default.
- W4220832005 creator A5078160296 @default.
- W4220832005 creator A5080853934 @default.
- W4220832005 creator A5081270812 @default.
- W4220832005 date "2022-03-13" @default.
- W4220832005 modified "2023-10-16" @default.
- W4220832005 title "Pentylenetetrazole-induced kindling rat model: miR-182 and miR-27b-3p mediated neuroprotective effect of thymoquinone in the hippocampus" @default.
- W4220832005 cites W144423133 @default.
- W4220832005 cites W1861458934 @default.
- W4220832005 cites W1875008998 @default.
- W4220832005 cites W1910831826 @default.
- W4220832005 cites W1973102533 @default.
- W4220832005 cites W1985238051 @default.
- W4220832005 cites W2001173515 @default.
- W4220832005 cites W2017398416 @default.
- W4220832005 cites W2017500569 @default.
- W4220832005 cites W2019467534 @default.
- W4220832005 cites W2024091295 @default.
- W4220832005 cites W2025560247 @default.
- W4220832005 cites W2025978099 @default.
- W4220832005 cites W2029795112 @default.
- W4220832005 cites W2060481603 @default.
- W4220832005 cites W2074162571 @default.
- W4220832005 cites W2080213498 @default.
- W4220832005 cites W2103946141 @default.
- W4220832005 cites W2107277218 @default.
- W4220832005 cites W2110256992 @default.
- W4220832005 cites W2119782911 @default.
- W4220832005 cites W2123002302 @default.
- W4220832005 cites W2126696582 @default.
- W4220832005 cites W2134629862 @default.
- W4220832005 cites W2141985400 @default.
- W4220832005 cites W2142174182 @default.
- W4220832005 cites W2153118030 @default.
- W4220832005 cites W2157680032 @default.
- W4220832005 cites W2157916750 @default.
- W4220832005 cites W2162143298 @default.
- W4220832005 cites W2312464259 @default.
- W4220832005 cites W2534113347 @default.
- W4220832005 cites W2550413675 @default.
- W4220832005 cites W2566715299 @default.
- W4220832005 cites W2579298745 @default.
- W4220832005 cites W2735467308 @default.
- W4220832005 cites W2744160143 @default.
- W4220832005 cites W2751861194 @default.
- W4220832005 cites W2762711294 @default.
- W4220832005 cites W2770489270 @default.
- W4220832005 cites W2786708975 @default.
- W4220832005 cites W2788560389 @default.
- W4220832005 cites W2802544271 @default.
- W4220832005 cites W2830852884 @default.
- W4220832005 cites W2897825874 @default.
- W4220832005 cites W2901377967 @default.
- W4220832005 cites W2915433652 @default.
- W4220832005 cites W2946271004 @default.
- W4220832005 cites W2946335709 @default.
- W4220832005 cites W2970200702 @default.
- W4220832005 cites W2970358232 @default.
- W4220832005 cites W2974914240 @default.
- W4220832005 cites W2987567173 @default.
- W4220832005 cites W2996327847 @default.
- W4220832005 cites W3003162628 @default.
- W4220832005 cites W3005128081 @default.
- W4220832005 cites W3037688992 @default.
- W4220832005 cites W3037768289 @default.
- W4220832005 cites W3048654124 @default.
- W4220832005 cites W3048920039 @default.
- W4220832005 cites W3085785996 @default.
- W4220832005 cites W3094084700 @default.
- W4220832005 cites W3136246414 @default.
- W4220832005 cites W3137317649 @default.
- W4220832005 cites W4246271082 @default.
- W4220832005 doi "https://doi.org/10.1080/01616412.2022.2051129" @default.
- W4220832005 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35282795" @default.
- W4220832005 hasPublicationYear "2022" @default.
- W4220832005 type Work @default.
- W4220832005 citedByCount "0" @default.
- W4220832005 crossrefType "journal-article" @default.
- W4220832005 hasAuthorship W4220832005A5017052920 @default.
- W4220832005 hasAuthorship W4220832005A5033832274 @default.
- W4220832005 hasAuthorship W4220832005A5041317514 @default.
- W4220832005 hasAuthorship W4220832005A5073706436 @default.
- W4220832005 hasAuthorship W4220832005A5074520805 @default.
- W4220832005 hasAuthorship W4220832005A5078160296 @default.
- W4220832005 hasAuthorship W4220832005A5080853934 @default.
- W4220832005 hasAuthorship W4220832005A5081270812 @default.
- W4220832005 hasConcept C100691959 @default.
- W4220832005 hasConcept C104317684 @default.
- W4220832005 hasConcept C118552586 @default.
- W4220832005 hasConcept C126322002 @default.
- W4220832005 hasConcept C145059251 @default.
- W4220832005 hasConcept C185592680 @default.