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- W4220833666 abstract "Adaptive plasticity processes are required involving neurons as well as non-neuronal cells to recover lost brain functions after an ischemic stroke. Recent studies show that gamma-Aminobutyric acid (GABA) has profound effects on glial and immune cell functions in addition to its inhibitory actions on neuronal circuits in the post-ischemic brain. Here, we provide an overview of how GABAergic neurotransmission changes during the first weeks after stroke and how GABA affects functions of astroglial and microglial cells as well as peripheral immune cell populations accumulating in the ischemic territory and brain regions remote to the lesion. Moreover, we will summarize recent studies providing data on the immunomodulatory actions of GABA of relevance for stroke recovery. Interestingly, the activation of GABA receptors on immune cells exerts a downregulation of detrimental anti-inflammatory cascades. Conversely, we will discuss studies addressing how specific inflammatory cascades affect GABAergic neurotransmission on the level of GABA receptor composition, GABA synthesis, and release. In particular, the chemokines CXCR4 and CX3CR1 pathways have been demonstrated to modulate receptor composition and synthesis. Together, the actual view on the interactions between GABAergic neurotransmission and inflammatory cascades points towards a specific crosstalk in the post-ischemic brain. Similar to what has been shown in experimental models, specific therapeutic modulation of GABAergic neurotransmission and inflammatory pathways may synergistically promote neuronal plasticity to enhance stroke recovery." @default.
- W4220833666 created "2022-04-03" @default.
- W4220833666 creator A5047812841 @default.
- W4220833666 creator A5087851175 @default.
- W4220833666 date "2022-03-23" @default.
- W4220833666 modified "2023-10-17" @default.
- W4220833666 title "Crosstalk Between GABAergic Neurotransmission and Inflammatory Cascades in the Post-ischemic Brain: Relevance for Stroke Recovery" @default.
- W4220833666 cites W106798729 @default.
- W4220833666 cites W145363236 @default.
- W4220833666 cites W1505903665 @default.
- W4220833666 cites W1531343696 @default.
- W4220833666 cites W1534553826 @default.
- W4220833666 cites W1536840470 @default.
- W4220833666 cites W1544820591 @default.
- W4220833666 cites W1551533003 @default.
- W4220833666 cites W1581974893 @default.
- W4220833666 cites W1598669426 @default.
- W4220833666 cites W1607151736 @default.
- W4220833666 cites W1755159888 @default.
- W4220833666 cites W176212822 @default.
- W4220833666 cites W1764789047 @default.
- W4220833666 cites W1848859766 @default.
- W4220833666 cites W1849769613 @default.
- W4220833666 cites W1877104861 @default.
- W4220833666 cites W1889592976 @default.
- W4220833666 cites W1892249233 @default.
- W4220833666 cites W1921741715 @default.
- W4220833666 cites W1947718130 @default.
- W4220833666 cites W1964041350 @default.
- W4220833666 cites W1964730250 @default.
- W4220833666 cites W1964841183 @default.
- W4220833666 cites W1964948396 @default.
- W4220833666 cites W1968219694 @default.
- W4220833666 cites W1968917479 @default.
- W4220833666 cites W1969109787 @default.
- W4220833666 cites W1969307826 @default.
- W4220833666 cites W1969583788 @default.
- W4220833666 cites W1970513158 @default.
- W4220833666 cites W1972124891 @default.
- W4220833666 cites W1973041420 @default.
- W4220833666 cites W1977640681 @default.
- W4220833666 cites W1978439344 @default.
- W4220833666 cites W1980201109 @default.
- W4220833666 cites W1986463724 @default.
- W4220833666 cites W1987265891 @default.
- W4220833666 cites W1989229171 @default.
- W4220833666 cites W1989821508 @default.
- W4220833666 cites W1990392929 @default.
- W4220833666 cites W1990567359 @default.
- W4220833666 cites W1992195114 @default.
- W4220833666 cites W1992836821 @default.
- W4220833666 cites W1994532676 @default.
- W4220833666 cites W1994799682 @default.
- W4220833666 cites W1995290394 @default.
- W4220833666 cites W1996024251 @default.
- W4220833666 cites W1998424611 @default.
- W4220833666 cites W1998494144 @default.
- W4220833666 cites W1999466129 @default.
- W4220833666 cites W2000917831 @default.
- W4220833666 cites W2001173861 @default.
- W4220833666 cites W2001481731 @default.
- W4220833666 cites W2002219675 @default.
- W4220833666 cites W2005804545 @default.
- W4220833666 cites W2006858748 @default.
- W4220833666 cites W2007327549 @default.
- W4220833666 cites W2008669330 @default.
- W4220833666 cites W2011116439 @default.
- W4220833666 cites W2011324056 @default.
- W4220833666 cites W2011567379 @default.
- W4220833666 cites W2016321438 @default.
- W4220833666 cites W2016676279 @default.
- W4220833666 cites W2017147451 @default.
- W4220833666 cites W2018685391 @default.
- W4220833666 cites W2022378061 @default.
- W4220833666 cites W2022681053 @default.
- W4220833666 cites W2025368995 @default.
- W4220833666 cites W2025461456 @default.
- W4220833666 cites W2029381684 @default.
- W4220833666 cites W2031773044 @default.
- W4220833666 cites W2031799130 @default.
- W4220833666 cites W2032681138 @default.
- W4220833666 cites W2033058124 @default.
- W4220833666 cites W2035221144 @default.
- W4220833666 cites W2040754796 @default.
- W4220833666 cites W2040868194 @default.
- W4220833666 cites W2041293915 @default.
- W4220833666 cites W2041675232 @default.
- W4220833666 cites W2043068492 @default.
- W4220833666 cites W2043441080 @default.
- W4220833666 cites W2043663764 @default.
- W4220833666 cites W2047216755 @default.
- W4220833666 cites W2047585900 @default.
- W4220833666 cites W2049230063 @default.
- W4220833666 cites W2050231827 @default.
- W4220833666 cites W2050320551 @default.
- W4220833666 cites W2050397606 @default.
- W4220833666 cites W2050510082 @default.
- W4220833666 cites W2050903454 @default.
- W4220833666 cites W2053079477 @default.
- W4220833666 cites W2053592840 @default.