Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220835533> ?p ?o ?g. }
- W4220835533 abstract "Fetal growth restriction (FGR) and pre-eclampsia with fetal growth restriction (PE/FGR) are high-risk perinatal diseases that may involve high levels of human chorionic gonadotropin (hCG) and mitochondrial dysfunction. However, little is known about how these factors affect placental function. We investigated how mitochondrial dysfunction and high hCG expression affected placental function in unexplained FGR and PE/FGR. We observed elevated expression of hCGβ and growth differentiation factor 15 mRNA and protein levels in the placenta with both diseases. Likewise, antiangiogenic factors, such as Ang2, IP10, sFlt1, IL8, IL1B, and TNFα, were also upregulated at the mRNA level. In addition, the expression of COXI and COXII which encoded by mitochondrial DNA were significantly decreased in both diseases, suggesting that mitochondrial translation was impaired. Treatment with hCG increased Ang2, IP10, IL8, and TNFα mRNA levels in a dose-dependent manner via the p38 and JNK pathways. Mitochondrial translation inhibitors increased hCGβ expression through stabilization of HIF1α, and increased IL8 and TNFα mRNA expression. These results revealed that high expression of hCG due to mitochondrial translational dysfunction plays an important role in the pathogenesis of FGR and PE/FGR." @default.
- W4220835533 created "2022-04-03" @default.
- W4220835533 creator A5004313573 @default.
- W4220835533 creator A5007606729 @default.
- W4220835533 creator A5018042617 @default.
- W4220835533 creator A5031542048 @default.
- W4220835533 creator A5043263475 @default.
- W4220835533 creator A5053761654 @default.
- W4220835533 creator A5059010005 @default.
- W4220835533 creator A5079543730 @default.
- W4220835533 date "2022-03-08" @default.
- W4220835533 modified "2023-10-14" @default.
- W4220835533 title "Mitochondrial dysfunction-induced high hCG associated with development of fetal growth restriction and pre-eclampsia with fetal growth restriction" @default.
- W4220835533 cites W1622697555 @default.
- W4220835533 cites W1849560193 @default.
- W4220835533 cites W1927376511 @default.
- W4220835533 cites W1968578271 @default.
- W4220835533 cites W1978681064 @default.
- W4220835533 cites W1984125311 @default.
- W4220835533 cites W1984970610 @default.
- W4220835533 cites W1988647189 @default.
- W4220835533 cites W1992608272 @default.
- W4220835533 cites W1998358627 @default.
- W4220835533 cites W2001338687 @default.
- W4220835533 cites W2009184602 @default.
- W4220835533 cites W2010004649 @default.
- W4220835533 cites W2010880312 @default.
- W4220835533 cites W2026409109 @default.
- W4220835533 cites W2035077205 @default.
- W4220835533 cites W2041967019 @default.
- W4220835533 cites W2048370637 @default.
- W4220835533 cites W2051209291 @default.
- W4220835533 cites W2064216090 @default.
- W4220835533 cites W2064253451 @default.
- W4220835533 cites W2070316275 @default.
- W4220835533 cites W2074658466 @default.
- W4220835533 cites W2077311976 @default.
- W4220835533 cites W2079231160 @default.
- W4220835533 cites W2084195855 @default.
- W4220835533 cites W2085483520 @default.
- W4220835533 cites W2093756791 @default.
- W4220835533 cites W2106365461 @default.
- W4220835533 cites W2119365719 @default.
- W4220835533 cites W2119408181 @default.
- W4220835533 cites W2127987607 @default.
- W4220835533 cites W2137916511 @default.
- W4220835533 cites W2143180984 @default.
- W4220835533 cites W2143764193 @default.
- W4220835533 cites W2148950320 @default.
- W4220835533 cites W2152215024 @default.
- W4220835533 cites W2155921188 @default.
- W4220835533 cites W2160469799 @default.
- W4220835533 cites W2161118526 @default.
- W4220835533 cites W2162563935 @default.
- W4220835533 cites W2167950650 @default.
- W4220835533 cites W2300647592 @default.
- W4220835533 cites W2472076754 @default.
- W4220835533 cites W2566620777 @default.
- W4220835533 cites W2580513581 @default.
- W4220835533 cites W2736793376 @default.
- W4220835533 cites W2760068726 @default.
- W4220835533 cites W2790688909 @default.
- W4220835533 cites W2901693839 @default.
- W4220835533 cites W3092675719 @default.
- W4220835533 cites W3134757762 @default.
- W4220835533 cites W4210702104 @default.
- W4220835533 cites W422643866 @default.
- W4220835533 doi "https://doi.org/10.1038/s41598-022-07893-y" @default.
- W4220835533 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35260712" @default.
- W4220835533 hasPublicationYear "2022" @default.
- W4220835533 type Work @default.
- W4220835533 citedByCount "3" @default.
- W4220835533 countsByYear W42208355332022 @default.
- W4220835533 countsByYear W42208355332023 @default.
- W4220835533 crossrefType "journal-article" @default.
- W4220835533 hasAuthorship W4220835533A5004313573 @default.
- W4220835533 hasAuthorship W4220835533A5007606729 @default.
- W4220835533 hasAuthorship W4220835533A5018042617 @default.
- W4220835533 hasAuthorship W4220835533A5031542048 @default.
- W4220835533 hasAuthorship W4220835533A5043263475 @default.
- W4220835533 hasAuthorship W4220835533A5053761654 @default.
- W4220835533 hasAuthorship W4220835533A5059010005 @default.
- W4220835533 hasAuthorship W4220835533A5079543730 @default.
- W4220835533 hasBestOaLocation W42208355331 @default.
- W4220835533 hasConcept C104317684 @default.
- W4220835533 hasConcept C105580179 @default.
- W4220835533 hasConcept C126322002 @default.
- W4220835533 hasConcept C127561419 @default.
- W4220835533 hasConcept C134018914 @default.
- W4220835533 hasConcept C16685009 @default.
- W4220835533 hasConcept C172680121 @default.
- W4220835533 hasConcept C24586158 @default.
- W4220835533 hasConcept C2775948956 @default.
- W4220835533 hasConcept C2776953305 @default.
- W4220835533 hasConcept C2779234561 @default.
- W4220835533 hasConcept C2780942790 @default.
- W4220835533 hasConcept C54355233 @default.
- W4220835533 hasConcept C71315377 @default.
- W4220835533 hasConcept C71924100 @default.
- W4220835533 hasConcept C86803240 @default.