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- W4220839663 abstract "Abstract Twenty‐five years ago, a new physiological preparation called the working heart–brainstem preparation (WHBP) was introduced with the claim it would provide a new platform allowing studies not possible before in cardiovascular, neuroendocrine, autonomic and respiratory research. Herein, we review some of the progress made with the WHBP, some advantages and disadvantages along with potential future applications, and provide photographs and technical drawings of all the customised equipment used for the preparation. Using mice or rats, the WHBP is an in situ experimental model that is perfused via an extracorporeal circuit benefitting from unprecedented surgical access, mechanical stability of the brain for whole cell recording and an uncompromised use of pharmacological agents akin to in vitro approaches. The preparation has revealed novel mechanistic insights into, for example, the generation of distinct respiratory rhythms, the neurogenesis of sympathetic activity, coupling between respiration and the heart and circulation, hypothalamic and spinal control mechanisms, and peripheral and central chemoreceptor mechanisms. Insights have been gleaned into diseases such as hypertension, heart failure and sleep apnoea. Findings from the in situ preparation have been ratified in conscious in vivo animals and when tested have translated to humans. We conclude by discussing potential future applications of the WHBP including two‐photon imaging of peripheral and central nervous systems and adoption of pharmacogenetic tools that will improve our understanding of physiological mechanisms and reveal novel mechanisms that may guide new treatment strategies for cardiorespiratory diseases. image" @default.
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- W4220839663 date "2022-04-07" @default.
- W4220839663 modified "2023-10-15" @default.
- W4220839663 title "Advancing respiratory–cardiovascular physiology with the working heart–brainstem preparation over 25 years" @default.
- W4220839663 cites W1484834707 @default.
- W4220839663 cites W1489364196 @default.
- W4220839663 cites W1517556389 @default.
- W4220839663 cites W1567348707 @default.
- W4220839663 cites W1648952992 @default.
- W4220839663 cites W1783175659 @default.
- W4220839663 cites W1840672965 @default.
- W4220839663 cites W1869943391 @default.
- W4220839663 cites W1926041874 @default.
- W4220839663 cites W1963530163 @default.
- W4220839663 cites W1971027471 @default.
- W4220839663 cites W1971288017 @default.
- W4220839663 cites W1977003032 @default.
- W4220839663 cites W1977962340 @default.
- W4220839663 cites W1982708121 @default.
- W4220839663 cites W1984725070 @default.
- W4220839663 cites W1992972887 @default.
- W4220839663 cites W1995806788 @default.
- W4220839663 cites W1999340472 @default.
- W4220839663 cites W2003563823 @default.
- W4220839663 cites W2005109616 @default.
- W4220839663 cites W2008072124 @default.
- W4220839663 cites W2009159343 @default.
- W4220839663 cites W2009758830 @default.
- W4220839663 cites W2010627844 @default.
- W4220839663 cites W2011451231 @default.
- W4220839663 cites W2016956534 @default.
- W4220839663 cites W2023357061 @default.
- W4220839663 cites W2025433228 @default.
- W4220839663 cites W2025872245 @default.
- W4220839663 cites W2025891499 @default.
- W4220839663 cites W2026718311 @default.
- W4220839663 cites W2029078782 @default.
- W4220839663 cites W2037688283 @default.
- W4220839663 cites W2037842203 @default.
- W4220839663 cites W2039645654 @default.
- W4220839663 cites W2043624136 @default.
- W4220839663 cites W2045362230 @default.
- W4220839663 cites W2050741716 @default.
- W4220839663 cites W2057140613 @default.
- W4220839663 cites W2057913521 @default.
- W4220839663 cites W2058193589 @default.
- W4220839663 cites W2063615964 @default.
- W4220839663 cites W2065043662 @default.
- W4220839663 cites W2070687545 @default.
- W4220839663 cites W2072552785 @default.
- W4220839663 cites W2072780124 @default.
- W4220839663 cites W2076616214 @default.
- W4220839663 cites W2079104859 @default.
- W4220839663 cites W2080264333 @default.
- W4220839663 cites W2080805045 @default.
- W4220839663 cites W2081155432 @default.
- W4220839663 cites W2082405299 @default.
- W4220839663 cites W2083189257 @default.
- W4220839663 cites W2085797519 @default.
- W4220839663 cites W2086376088 @default.
- W4220839663 cites W2095263752 @default.
- W4220839663 cites W2098105306 @default.
- W4220839663 cites W2102148167 @default.
- W4220839663 cites W2104129416 @default.
- W4220839663 cites W2106985452 @default.
- W4220839663 cites W2107205080 @default.
- W4220839663 cites W2109801615 @default.
- W4220839663 cites W2110557297 @default.
- W4220839663 cites W2115643876 @default.
- W4220839663 cites W2116030040 @default.
- W4220839663 cites W2116202065 @default.
- W4220839663 cites W2116395848 @default.
- W4220839663 cites W2116807287 @default.
- W4220839663 cites W2118954133 @default.
- W4220839663 cites W2120709057 @default.
- W4220839663 cites W2120934356 @default.
- W4220839663 cites W2124360135 @default.