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- W4220843170 abstract "The unfolded protein response (UPR) maintains homeostasis of the endoplasmic reticulum (ER). Residing in the ER membrane, the UPR mediator Ire1 deploys its cytoplasmic kinase-endoribonuclease domain to activate the key UPR transcription factor Xbp1 through non-conventional splicing of Xbp1 mRNA. Ire1 also degrades diverse ER-targeted mRNAs through regulated Ire1-dependent decay (RIDD), but how it spares Xbp1 mRNA from this decay is unknown. Here, we identify binding sites for the RNA-binding protein Pumilio in the 3'UTR Drosophila Xbp1. In the developing Drosophila eye, Pumilio binds both the Xbp1unspliced and Xbp1spliced mRNAs, but only Xbp1spliced is stabilized by Pumilio. Furthermore, Pumilio displays Ire1 kinase-dependent phosphorylation during ER stress, which is required for its stabilization of Xbp1spliced. hIRE1 can phosphorylate Pumilio directly, and phosphorylated Pumilio protects Xbp1spliced mRNA against RIDD. Thus, Ire1-mediated phosphorylation enables Pumilio to shield Xbp1spliced from RIDD. These results uncover an unexpected regulatory link between an RNA-binding protein and the UPR." @default.
- W4220843170 created "2022-04-03" @default.
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- W4220843170 date "2022-03-24" @default.
- W4220843170 modified "2023-09-26" @default.
- W4220843170 title "Pumilio protects Xbp1 mRNA from regulated Ire1-dependent decay" @default.
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- W4220843170 cites W1976290313 @default.
- W4220843170 cites W1977603207 @default.
- W4220843170 cites W1981515291 @default.
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- W4220843170 cites W1986737010 @default.
- W4220843170 cites W1990136127 @default.
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- W4220843170 cites W2021145710 @default.
- W4220843170 cites W2022802536 @default.
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- W4220843170 cites W2038916704 @default.
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- W4220843170 doi "https://doi.org/10.1038/s41467-022-29105-x" @default.
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