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- W4220846103 abstract "Here we noted significantly downregulated miR-1-3p in gastric cancer (GC) tissue compared with adjacent normal tissue through qRT-PCR. Lowly expressed miR-1-3p correlated GC progression. Overexpressing miR-1-3p could restrain tumor-relevant cell behaviors in GC, while miR-1-3p inhibitor treatment triggered the opposite results. Moreover, dual-luciferase reporter gene detection identified specific binding sites of miR-1-3p in CENPF 3'untranslated region. Upregulating miR-1-3p constrained cell progression of GC via CENPF downregulation. Western blot, qRT-PCR and dual-luciferase detections manifested that miR-1-3p negatively mediated CENPF expression in GC cells. Thus, we demonstrated that miR-1-3p negatively mediated CENPF to hamper GC progression. CENPF may be an underlying target for GC therapy." @default.
- W4220846103 created "2022-04-03" @default.
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- W4220846103 date "2022-03-28" @default.
- W4220846103 modified "2023-10-10" @default.
- W4220846103 title "MiR-1-3p targets CENPF to repress tumor-relevant functions of gastric cancer cells" @default.
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- W4220846103 doi "https://doi.org/10.1186/s12876-022-02203-2" @default.
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