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- W4220846320 endingPage "425" @default.
- W4220846320 startingPage "425" @default.
- W4220846320 abstract "The striatal region Area X plays an important role during song learning, sequencing, and variability in songbirds. A previous study revealed that neurotoxic damage within Area X results in micro and macrostructural changes across the entire brain, including the downstream dorsal thalamus and both the upstream pallial nucleus HVC (proper name) and the deep cerebellar nuclei (DCN). Here, we specify these changes on cellular and gene expression levels. We found decreased cell density in the thalamic and cerebellar areas and HVC, but it was not related to neuronal loss. On the contrary, perineuronal nets (PNNs) in HVC increased for up to 2 months post-lesion, suggesting their protecting role. The synaptic plasticity marker Forkhead box protein P2 (FoxP2) showed a bi-phasic increase at 8 days and 3 months post-lesion, indicating a massive synaptic rebuilding. The later increase in HVC was associated with the increased number of new neurons. These data suggest that the damage in the striatal vocal nucleus induces cellular and gene expression alterations in both the efferent and afferent destinations. These changes may be long-lasting and involve plasticity and neural protection mechanisms in the areas directly connected to the injury site and also to distant areas, such as the cerebellum." @default.
- W4220846320 created "2022-04-03" @default.
- W4220846320 creator A5007699786 @default.
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- W4220846320 creator A5087046972 @default.
- W4220846320 date "2022-03-10" @default.
- W4220846320 modified "2023-09-25" @default.
- W4220846320 title "Striatal Injury Induces Overall Brain Alteration at the Pallial, Thalamic, and Cerebellar Levels" @default.
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