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• W4220846395 abstract "BackgroundSoy foods may contribute to the beneficial health effects of healthy plant-based diets on the risk to develop cardiovascular disease (CVD). However, their effects on vascular function have hardly been studied.ObjectiveTo investigate longer-term effects of soy nut consumption on vascular function and cardiometabolic risk markers in healthy older men and women.DesignTwenty-three healthy participants (age: 60–70 years; BMI: 20–30 kg/m2) participated in a randomized, controlled, single-blinded cross-over trial with an intervention (67 g/day of soy nuts providing 25.5 g protein and 174 mg isoflavones) and control period (no nuts) of 16 weeks, separated by eight weeks wash-out. Adults followed the Dutch food-based dietary guidelines.ResultsNo serious adverse events were reported and the soy nut regime was well tolerated. Body weights remained stable during the whole study. A higher protein (3.1 energy percent [En%]) and a lower carbohydrate intake (2.0 En%) was observed during the intervention period. Total fat intake was comparable, but that of saturated (−1.3 En%), cis-monounsaturated (−1.5 En%) and cis-polyunsaturated fatty acids (+1.9 En%) differed. Serum isoflavone concentrations were higher after the intervention as compared with the control period (daidzein: 127.8 ng/mL; 95% CI: 74.3–181.3 ng/mL; p < 0.001 and genistein: 454.2 ng/mL; 95% CI: 266.6–641.8 ng/mL; p < 0.001). Brachial artery flow-mediated vasodilation was 1.48 percent points (pp; 95% CI: 0.08–2.89 pp; p = 0.040) higher following soy nut intake. The carotid artery reactivity response and arterial stiffness did not differ. Serum LDL-cholesterol was lower (0.17 mmol/L; 95% CI: 0.02–0.32 mmol/L; p = 0.027), while HDL-cholesterol and triacylglycerol concentrations were comparable. Mean arterial pressure (MAP) was lower (3 mmHg; 95% CI: 0–6 mmHg; p = 0.035).ConclusionsLonger-term soy nut intake as part of a healthy diet improved endothelial function, LDL-cholesterol concentrations and MAP levels, suggesting mechanisms by which an increased soy food intake beneficially affects CVD risk in older adults.Registered under ClinicalTrials.gov Identifier no. NCT03627637." @default.
• W4220846395 created "2022-04-03" @default.
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• W4220846395 date "2022-05-01" @default.
• W4220846395 modified "2023-10-18" @default.
• W4220846395 title "Longer-term soy nut consumption improves vascular function and cardiometabolic risk markers in older adults: Results of a randomized, controlled cross-over trial" @default.
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• W4220846395 doi "https://doi.org/10.1016/j.clnu.2022.03.014" @default.
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