Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220847189> ?p ?o ?g. }
- W4220847189 abstract "Extracellular nanovesicles, particularly exosomes, can deliver their diverse bioactive biomolecular content, including miRNAs, proteins, and lipids, thus providing a context for investigating the capability of exosomes to induce stem cells toward lineage-specific cells and tissue regeneration. In this study, it is demonstrated that rat subventricular zone neural stem cell-derived exosomes (rSVZ-NSCExo) can control neural-lineage specification of human mesenchymal stem cells (hMSCs). Microarray analysis shows that the miRNA content of rSVZ-NSCExo is a faithful representation of rSVZ tissue. Through immunocytochemistry, gene expression, and multi-omics analyses, the capability to use rSVZ-NSCExo to induce hMSCs into a neuroglial or neural stem cell phenotype and genotype in a temporal and dose-dependent manner via multiple signaling pathways is demonstrated. The current study presents a new and innovative strategy to modulate hMSCs fate by harnessing the molecular content of exosomes, thus suggesting future opportunities for rSVZ-NSCExo in nerve tissue regeneration." @default.
- W4220847189 created "2022-04-03" @default.
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- W4220847189 date "2022-03-28" @default.
- W4220847189 modified "2023-10-10" @default.
- W4220847189 title "Xenogenic Neural Stem Cell‐Derived Extracellular Nanovesicles Modulate Human Mesenchymal Stem Cell Fate and Reconstruct Metabolomic Structure" @default.
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- W4220847189 doi "https://doi.org/10.1002/adbi.202101317" @default.
- W4220847189 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35347890" @default.
- W4220847189 hasPublicationYear "2022" @default.
- W4220847189 type Work @default.