Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220850504> ?p ?o ?g. }
- W4220850504 endingPage "534" @default.
- W4220850504 startingPage "534" @default.
- W4220850504 abstract "Intercellular communication between monocytes/macrophages and cells involved in tissue regeneration, such as mesenchymal stromal cells (MSCs) and primary tissue cells, is essential for tissue regeneration and recovery of homeostasis. Typically, in the final phase of the inflammation-resolving process, this intercellular communication drives an anti-inflammatory immunomodulatory response. To obtain a safe and effective treatment to counteract the cytokine storm associated with a disproportionate immune response to severe infections, including that associated with COVID-19, by means of naturally balanced immunomodulation, our group has standardized the production under GMP-like conditions of a secretome by coculture of macrophages and MSCs. To characterize this proteome, we determined the expression of molecules related to cellular immune response and tissue regeneration, as well as its possible toxicity and anti-inflammatory potency. The results show a specific molecular pattern of interaction between the two cell types studied, with an anti-inflammatory and regenerative profile. In addition, the secretome is not toxic by itself on human PBMC or on THP-1 monocytes and prevents lipopolysaccharide (LPS)-induced growth effects on those cell types. Finally, PRS CK STORM prevents LPS-induced TNF-A and IL-1Β secretion from PBMC and from THP-1 cells at the same level as hydrocortisone, demonstrating its anti-inflammatory potency." @default.
- W4220850504 created "2022-04-03" @default.
- W4220850504 creator A5001432358 @default.
- W4220850504 creator A5009681249 @default.
- W4220850504 creator A5012960825 @default.
- W4220850504 creator A5022697108 @default.
- W4220850504 creator A5022868289 @default.
- W4220850504 creator A5026257650 @default.
- W4220850504 creator A5042608198 @default.
- W4220850504 creator A5043469567 @default.
- W4220850504 creator A5044135684 @default.
- W4220850504 creator A5050344289 @default.
- W4220850504 creator A5053703453 @default.
- W4220850504 creator A5055729181 @default.
- W4220850504 creator A5059782439 @default.
- W4220850504 creator A5063451606 @default.
- W4220850504 creator A5066989773 @default.
- W4220850504 creator A5085867704 @default.
- W4220850504 creator A5087243142 @default.
- W4220850504 date "2022-03-31" @default.
- W4220850504 modified "2023-09-30" @default.
- W4220850504 title "Cytokine Profile and Anti-Inflammatory Activity of a Standardized Conditioned Medium Obtained by Coculture of Monocytes and Mesenchymal Stromal Cells (PRS CK STORM)" @default.
- W4220850504 cites W1535567348 @default.
- W4220850504 cites W1590988658 @default.
- W4220850504 cites W1970600368 @default.
- W4220850504 cites W1977983409 @default.
- W4220850504 cites W1979043688 @default.
- W4220850504 cites W1980220254 @default.
- W4220850504 cites W1986650979 @default.
- W4220850504 cites W1989029018 @default.
- W4220850504 cites W1994942139 @default.
- W4220850504 cites W1996619509 @default.
- W4220850504 cites W2000115558 @default.
- W4220850504 cites W2001326592 @default.
- W4220850504 cites W2010993726 @default.
- W4220850504 cites W2016744980 @default.
- W4220850504 cites W2020744745 @default.
- W4220850504 cites W2024326908 @default.
- W4220850504 cites W2033373261 @default.
- W4220850504 cites W2033885016 @default.
- W4220850504 cites W2034514595 @default.
- W4220850504 cites W2046422749 @default.
- W4220850504 cites W2047054188 @default.
- W4220850504 cites W2060766291 @default.
- W4220850504 cites W2063295894 @default.
- W4220850504 cites W2069399162 @default.
- W4220850504 cites W2072270184 @default.
- W4220850504 cites W2077861814 @default.
- W4220850504 cites W2083156208 @default.
- W4220850504 cites W2086673145 @default.
- W4220850504 cites W2089592611 @default.
- W4220850504 cites W2099570622 @default.
- W4220850504 cites W2106466636 @default.
- W4220850504 cites W2116259052 @default.
- W4220850504 cites W2120108270 @default.
- W4220850504 cites W2121999038 @default.
- W4220850504 cites W2139946512 @default.
- W4220850504 cites W2143516276 @default.
- W4220850504 cites W2155948584 @default.
- W4220850504 cites W2161704645 @default.
- W4220850504 cites W2183142442 @default.
- W4220850504 cites W2186832235 @default.
- W4220850504 cites W2277734620 @default.
- W4220850504 cites W2288860277 @default.
- W4220850504 cites W2313156113 @default.
- W4220850504 cites W2314376988 @default.
- W4220850504 cites W2316890337 @default.
- W4220850504 cites W2322623562 @default.
- W4220850504 cites W2331176038 @default.
- W4220850504 cites W2414225912 @default.
- W4220850504 cites W2483196423 @default.
- W4220850504 cites W2530424978 @default.
- W4220850504 cites W2565439953 @default.
- W4220850504 cites W2588276914 @default.
- W4220850504 cites W2618209467 @default.
- W4220850504 cites W2732557031 @default.
- W4220850504 cites W2757687260 @default.
- W4220850504 cites W2773545354 @default.
- W4220850504 cites W2799294729 @default.
- W4220850504 cites W2801946181 @default.
- W4220850504 cites W2820041734 @default.
- W4220850504 cites W2895752892 @default.
- W4220850504 cites W2902945171 @default.
- W4220850504 cites W2921393982 @default.
- W4220850504 cites W2951565319 @default.
- W4220850504 cites W2967492826 @default.
- W4220850504 cites W2990337693 @default.
- W4220850504 cites W2999225761 @default.
- W4220850504 cites W3003567576 @default.
- W4220850504 cites W3011511215 @default.
- W4220850504 cites W3011976215 @default.
- W4220850504 cites W3015401733 @default.
- W4220850504 cites W3023264778 @default.
- W4220850504 cites W3032256921 @default.
- W4220850504 cites W3038977158 @default.
- W4220850504 cites W3041884008 @default.
- W4220850504 cites W3152980057 @default.
- W4220850504 cites W52273448 @default.