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• W4220851055 abstract "The aim of this work has been to establish and validate a simple and efficient method to detect the concentration of inulin-type fructan CPA from the roots of Codonopsis pilosula (Franch.) Nannf. in biosamples, and then apply it to evaluate the pharmacokinetics behavior, distribution character in tissue and excretion in mice. In this work, fluorescein isothiocyanate (FITC) was used to label CPA. Then FCPA was intravenously and orally administered to mice at different doses. In both i.v and p.o administration, FCPA concentration slowly declined in the circulatory system with a much longer T1/2 and MRT. After p.o administration, the area under the time curve (AUC0-∞) was dose-dependently increased. Taken together, FCPA showed poor absorption and wide tissue distribution. These pharmacokinetic results yield helpful insights into the pharmacological actions of FCPA." @default.
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• W4220851055 date "2022-01-01" @default.
• W4220851055 modified "2023-10-12" @default.
• W4220851055 title "Pharmacokinetics, distribution and excretion of inulin-type fructan CPA after oral or intravenous administration to mice" @default.
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• W4220851055 doi "https://doi.org/10.1039/d1fo04327g" @default.
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